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ANP, BNP, and CNP enhance bradycardic responses to cardiopulmonary chemoreceptor activation in conscious sheep

, : ANP, BNP, and CNP enhance bradycardic responses to cardiopulmonary chemoreceptor activation in conscious sheep. American Journal of Physiology 280(1): 82-R288

Thomas, Colleen J., Clive N. May, Atul D. Sharma, and Robyn L. Woods. ANP, BNP, and CNP enhance bradycardic responses to cardiopulmonary chemoreceptor activation in conscious sheep. Am J Physiol Regulatory Integrative Comp Physiol 280: R282-R288, 2001.--We demonstrated previously that atrial natriuretic peptide (ANP) enhances reflex bradycardia to intravenous serotonin [5-hydroxytryptamine (5-HT)] (von Bezold-Jarisch reflex) in rats. To determine whether 1) ANP affects this cardiopulmonary vagal reflex in another species and 2) B-type (BNP) and C-type (CNP) natriuretic peptides share with ANP the ability to modulate this reflex, we used intravenous phenylbiguanide (PBG), a 5-HT3 agonist, as the stimulus to evoke a von Bezold-Jarisch reflex (dose-related, reproducible bradycardia) in conscious adult sheep (n = 5). Three doses of PBG (13 [plus or minus] 3, 20 [plus or minus] 3, and 31 [plus or minus] 4 mg/kg) injected into the jugular vein caused reflex cardiac slowing of -7 [plus or minus] 1, -15 [plus or minus] 2, and -36 [plus or minus] 3 beats/min, respectively, under control conditions. These doses of PBG were repeated during infusions of ANP, BNP, or CNP (10 pmol kg-1 min-1 iv), or vehicle (normal saline). Each of the natriuretic peptides significantly (P < 0.05) enhanced the sensitivity of bradycardic responses to PBG by 94 [plus or minus] 8% (ANP), 142 [plus or minus] 55% (BNP), and 61 [plus or minus] 16% (CNP). Thus not only did ANP sensitize cardiopulmonary chemoreceptor activation in a species with resting heart rate close to that in humans, but BNP and CNP also enhanced von Bezold-Jarisch reflex activity in conscious sheep. Reprinted by permission of the publisher.


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