geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Acute hormonal response to sublingual androstenediol intake in young men


, : Acute hormonal response to sublingual androstenediol intake in young men. Journal of Applied Physiology 92(1): 2-6

The effectiveness of orally ingested androstenediol in raising serum testosterone concentrations may be limited because of hepatic breakdown of the ingested androgens. Because androstenediol administered sublingually with cyclodextrin bypasses first-pass hepatic catabolism, we evaluated the acute hormonal response to sublingual cyclodextrin androstenediol supplement in young men. Eight men (22.9 [plus or minus] 1.2 yr) experienced in strength training consumed either 20 mg androstenediol in a sublingual cyclodextrin tablet (Sl Diol) or placebo (Pl) separated by at least 1 wk in a randomized, double-blind, crossover manner. Blood samples were collected before supplementation and at 30-min intervals for 3 h after supplementation. Serum hormone concentrations did not change with Pl. Serum androstenedione concentrations were increased (P < 0.05) above baseline (11.2 [plus or minus] 1.1 nmol/l) with Sl Diol from 60 to 180 min after intake and reached a peak concentration of 25.2 [plus or minus] 2.9 nmol/l at 120 min. Serum free testosterone concentrations were increased from 86.2 [plus or minus] 9.1 pmol/l with Sl Diol from 30 to 180 min and reached a peak concentration of 175.4 [plus or minus] 12.2 pmol/l at 60 min. Serum total testosterone concentrations increased above basal (25.6 [plus or minus] 2.3 nmol/l) from 30 to 180 min with Sl Diol and reached a peak concentration of 47.9 + 2.9 nmol/l at 60 min. Serum estradiol concentrations were elevated (P < 0.05) above baseline (0.08 [plus or minus] 0.01 nmol/l) from 30 to 180 min with Sl Diol and reached 0.14 [plus or minus] 0.02 nmol/l at 180 min. These data indicate that sublingual cyclodextrin androstenediol intake increases serum androstenedione, free testosterone, total testosterone, and estradiol concentrations. Reprinted by permission of the publisher.

US$29.90


Other references

Croy, C.; Buehrle, K.; Austin Szwak, J., 2017: Clindamycin-associated acute generalized exanthematous pustulosis. Acute generalized exanthematous pustulosis (AGEP) is a rare, severe cutaneous reaction that usually occurs following medication exposure. Clindamycin has rarely been linked to dermatologic side effects, including AGEP. This report details the case...

Francis E.H., 1975: Dunbar. Pages 93-106 1975

Dhillon, J.; Mohanty, S.K.; Kim, T.; Sexton, W.J.; Powsang, J.; Spiess, P.E., 2014: Spectrum of renal pathology in adult patients with congenital renal anomalies-a series from a tertiary cancer center. Congenital renal anomalies (CRAs) detected in adults include horseshoe kidney (HK), crossed renal ectopia, and malrotation. Congenital renal anomalies are rare, and renal lesions associated with CRA are rarer. Thirteen patients (11 men and 2 women...

Sanfilippo, S.; Ragusa, R.M.; Scillato, F.; Ruggeri, M.; Neri, G., 1988: Fragile X expression in normal and mentally retarded subjects: effect of treatment with an antifolic agent. Expression of the fragile site fra(X) (q27.3) in peripheral lymphocytes was evaluated in mentally retarded patients and in normal control individuals before and after administration of the antifolic agent trimethoprim for 7 days. This treatment wa...

Koehler., 1904: Ophiures nouvelles on peu connues. Memoires de la Societe Zoologique de France, XVII 54-119

Perrin, P.W., 1982: Post-storage cabbage responds to light. Cabbages stored for over 6 months in the dark at high RH (97%) and 1 degrees C became greener when exposed to light at 10 degrees for 7 days. The vitamin C content of the outer leaves increased from 2.5 to 24 mg/100 g under illumination.

Nichols, J.E.; Niles, J.A.; Roberts, N.J., 2001: Human lymphocyte apoptosis after exposure to influenza A virus. Infection of humans with influenza A virus (IAV) results in a severe transient leukopenia. The goal of these studies was to analyse possible mechanisms behind this IAV-induced leukopenia with emphasis on the potential induction of apoptosis of lym...

Ditkoff, B.A.n; Marvin, M.R.; Yemul, S.; Shi, Y.J.; Chabot, J.; Feind, C.; Gerfo, P.L., 1996: Detection of circulating thyroid cells in peripheral blood. Background. Detection of circulating malignant thyroid cells may provide a method to identify postoperative patients at risk for metastatic thyroid cancer. Methods. On the basis of tissue specificity of thyroglobulin gene expression and the sensit...

Namdari, H.; Hughes, J.; Jacobs, K.; Rose, S.; Bolus, G.; Delvecchio, V., 1998: Gram stain and Rep-PCR fingerprinting used for diagnosis and characterization of Corynebacterium pseudodiphthericum associated with pneumonia. Abstracts of the General Meeting of the American Society for Microbiology 98: 169

Sunidhi ; Bhandal, I.S., 1992: Physiology of salt tolerance in durum wheat. Salinity caused a reduction in germination and growth of all cultivars of Triticum durum, although cv. SQLA was salt tolerant.