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Anti-b2 glycoprotein I (b2GPI) autoantibodies recognize an epitope on the first domain of b2GPI


, : Anti-b2 glycoprotein I (b2GPI) autoantibodies recognize an epitope on the first domain of b2GPI. Proceedings of the National Academy of Sciences of the United States of America 95(26): 542-6

The identity of the epitopes recognized by phospholipid-binding plasma protein b2 glycoprotein I (b2GPI) autoantibodies was investigated. These autoantibodies were once believed to bind directly to cardiolipin (CL), but it has since been established that their epitopes are on b2GPI bound to phospholipid. The antigenic specificity of anti-CL antibodies (aCL) from 11 patients was determined by investigating the ability of various domain-deleted b2GPI to inhibit the binding of aCL to wild-type b2GPI. All 11 aCL tested were specific for domain 1 of b2GPI.

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