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C-myc and H-ras cellular oncogenes and human papillomavirus in cervical carcinoma


, : C-myc and H-ras cellular oncogenes and human papillomavirus in cervical carcinoma. Zhonghua Weishengwuxue He Mianyixue Zazhi 15(5): 347-351

To analyze the role of human papillomavirus (HPV) infection and C-myc and H-ras oncogene activation in development of cervical carcinoma, 60 biopsies from cervical carcinoma patients were examined. HPV DNA was detected by consensus polymerase chain reaction. In addition, the same Dias have been analysed for amplifications the C-myc, H-ras gene loci by Southern blotting. The results showed a HPV positive rate of 85% (51/60) in 60 cervical carcinoma biopsy tissues. HPV 16 sequences were detected in a total of 51 (78.43%) and HPV 18 sequences in 11 of the 51 (21.56%). Amplification of C-myc oncogene was found in 19/60 cancer, of which 13 were HPV 16 positive, and three also positive for HPV 18. The amplification of ras oncogene was detected in 4/60 specimens. The amplification of myc was more frequently amplified than that of ras. It suggests that C-myc plays a role in the carcinogenesis of HPV 16 and HPV 18. Therefore, it is most likely that the activation of protooncogenes may result in the insertion of HPV16 DNA into cellular genomes.

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