geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Cell proliferation without neurogenesis in adult primate neocortex


, : Cell proliferation without neurogenesis in adult primate neocortex. Science 294(5549): 2127-2130

A recent assertion that new neurons are continually added to the neocortex of adult macaque monkeys has profound implications for understanding the cellular mechanisms of higher cognitive functions. Here we searched for neurogenesis in adult macaques by using immunofluorescent triple labeling for the DNA-replication indicator, bromodeoxyuridine (BrdU), and neuronal and glial cell markers. Although numerous BrdU-labeled cells were distributed throughout the cerebral wall, including the neocortex, these were identified as nonneuronal cells; evidence for newly generated neurons was limited to the hippocampus and olfactory bulb. Thus, our results do not substantiate the claim of neurogenesis in normal adult primate neocortex. Copyright 2001 by the AAAS.

US$19.90

PMID: 11739948

DOI: 10.1126/science.1065467


Other references

Favier, J.F., 1983: Results of three years' weed control trials in sunflower crops. The French Plant Protection Service conducted trials in sunflower crops for 3 years and the following conclusions were reached: weed control with 1.8 kg neburon + 1.2 kg terbutryn/ha pre-em. was unreliable; 2.932 kg EPTC/ha incorporated pre-sowing...

Nemoto, Y., 1970: Surgical technic of intestinal anastomosis. Geka Chiryo. Surgical Therapy 22(1): 21-31

Clayton, G.; Colthurst, JRJ.; Higgs, K.; Jones, GL.; Keegan, JB., 1977: Tournaisian miospores and conodonts from County Kilkenny. Bulletin geol Surv Ir, 22: 99-106

Silva Rafael B.; Cruz, I.; Zanuncio, J.C.; Figueiredo Maria de Lourdes C.; Zanuncio Teresinha V.; Serrao, J.E., 2013: Spodoptera frugiperda JE Smith Lepidoptera Noctuidae eggs as alternative food for rearing of lady beetles Eriopis connexa Germar Coleoptera Coccinellidae. Eriopis connexa (Germar) (Coleoptera: Coccinellidae) is an important predator with potential for biological control of insect pests. This research evaluated the development of E. connexa larvae fed on fresh eggs of Spodoptera frugiperda (J.E. Smit...

Kocic, G.; Bjelakovic, L.; Bjelakovic, B.; Jevtoci-Stoimenov, T.; Sokolovic, D.; Cvetkovic, T.; Kocic, H.; Stojanovic, S.; Langerholc, T.; Jonovic, M., 2015: Impact of folic acid supplementation on single- and double-stranded RNA degradation in human colostrum and mature milk. Sufficient intake of folic acid is necessary for normal embryogenesis, fetal, and neonatal development. Folic acid facilitates nucleic acid internalization, and protects cellular DNA from nuclease degradation. Human milk contains enzymes, antimicr...

Carasso, A.S., 2013: Hazardous Continuation Backward in Time in Nonlinear Parabolic Equations, and an Experiment in Deblurring Nonlinearly Blurred Imagery. Identifying sources of ground water pollution, and deblurring nanoscale imagery as well as astronomical galaxy images, are two important applications involving numerical computation of parabolic equations backward in time. Surprisingly, very littl...

Wahl, D., 1977: Lingering fracture of the femoral neck-a rare overstrain-injury. The author refers to 2 young patients with spontaneous fractures of the femoral neck. The fatigue fracture of the healthy neck of the femur is extremely rare. The clinical picture and general problems, as well as the diagnostic and therapeutic asp...

Marnette, J.M.; Creemers, E.; Trotteur, G.; Limet, R., 1995: Results of an exclusion technique for treatment of abdominal aortic aneurysm. An exclusion technique for the treatment of abdominal aortic aneurysm was used in six patients considered to be at high operative risk mainly because of chronic pulmonary disease. There were no deaths or immediate major complications. Thrombosis o...

Pyle R.L., 1991: Spring season march 1 may 31 1991 hawaiian islands region. American Birds 45(3): 498-499

Cohen, S.A.; Ihrig, K.; Lott, R.S.; Kerrick, J.M., 1998: Risperidone for aggression and self-injurious behavior in adults with mental retardation. Risperidone has proven efficacy with reduced likelihood of causing extrapyramidal symptoms in the treatment of schizophrenia. Initial work suggests its utility in the management of aggression and self injury in patients with mental retardation. Th...