+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Distribution of PYY receptors in human fat cells: an antilipolytic system alongside the a2-adrenergic system

, : Distribution of PYY receptors in human fat cells: an antilipolytic system alongside the a2-adrenergic system. American Journal of Physiology 265: 4-80

The antilipolytic effect of peptide YY (PYY) and neuropeptide Y has recently been shown in human adipocytes. PYY receptors were investigated in three human adipose deposits. A greater number of 125I-labeled PYY binding sites was found in femoral adipocyte membranes (maximal binding = 40 [plus or minus] 4 fmol/mg protein; dissociation constant = 0.3 [plus or minus] 0.1 nM) when compared with mammary and pericolonic adipose tissue. PYY receptors, like a2-adrenergic sites, were largely expressed in femoral fat cells. Such a distribution was not specific either to inhibitory or to stimulating adenylyl cyclase systems since adenosine A1 and b-adrenergic receptors were more numerous in pericolonic adipocytes. On isolated adipocytes, PYY (10-7 M) inhibited lipolysis by 58 [plus or minus] 2% in femoral and 14 [plus or minus] 4% in pericolonic fat cells; epinephrine had the following similar response: 62 [plus or minus] 5 and 26 [plus or minus] 8%, respectively. A close relationship between the number of a2-sites and PYY sites and the antilipolytic effects initiated by PYY and an a2-agonist was observed. No significant differences were noted in the amount of Gi proteins in femoral and pericolonic adipocyte membranes. Reprinted by permission of the publisher. .


Other references

Lazzari, A., 1961: Treatment of obliterating arteriopathy of the lower extremities with the "by-pass" type of autogenous great saphenous vein transplant. Bollettino - Societa Medico Chirurgica Cremona 15: 173-181

El-Tarras, M.; Haroun, I.E.-Zeany, B., 1978: Post gamma radiation effects on oxidative stability of vegetable oils. Rivista italiana delle sostanze grasse: 55 (4) 113-115

Sievenpiper, J.L.; Jenkins, D.J.A.; Josse, R.G.; Vuksan, V., 2001: Dilution of the 75-g oral glucose tolerance test improves overall tolerability but not reproducibility in subjects with different body compositions. Poor reproducibility of the 75-g oral glucose tolerance test (75-g OGTT) is a major criticism. To test whether dilution might be a contributor, we studied the effect of administering it at 300, 600, and 900 ml on the coefficient of variation (CV)...

Anonymous, 1978: Malaria prevention unpardonably neglected. Mmw, Munchener Medizinische Wochenschrift 120(6): 151-151

Johnston, De, 1982: Acari Mites. Synopsis and classification of living organisms Sybil P Parker editor in chief: 117

Bergman, P.J.; MacEwen, E.G.; Kurzman, I.D.; Henry, C.J.; Hammer, A.S.; Knapp, D.W.; Hale, A.; Kruth, S.A.; Klein, M.K.; Klausner, J.; Norris, A.M.; McCaw, D.; Straw, R.C.; Withrow, S.J., 1996: Amputation and carboplatin for treatment of dogs with osteosarcoma: 48 cases (1991 to 1993). Forty-eight dogs with histologically confirmed appendicular osteosarcoma (OSA) entered a prospective clinical trial evaluating treatment with amputation and up to 4 doses of carboplatin (300 mg/msuperscript 2 i.v.) given every 21 days. The median...

Sridharan, S.; Amin, M.R.; Branski, R.C., 2016: Vocal fold immobility after finger sweep self-extrusion of impacted food in a choking victim with resolution following laryngeal mask ventilation. We report a case of unilateral vocal fold immobility in a 57-year-old woman that occurred subsequent to a choking episode, which she resolved by removing impacted food with a finger sweep. Other than the unilateral immobility, no abnormality of th...

Komiya, I.; Shirasaka, T.; Umezu, Y.; Tachibana, M.; Izumi, T., 2004: Patient dose measurement with fluorescent glass dosimeter: characteristics evaluation and patient skin dose measurement in abdominal interventional radiology. In this study, we investigated the usefulness of the fluorescent glass dosimeter for measuring patient dose. The fluorescent glass dosimeter is constructed of a glass element and its holder. One type has a tin (Sn) filter and the other does not. T...

Rad, A.Shahrokhi.; Siadat, H.; Monzavi, A.; Mangoli, A-Ali., 2007: Full mouth rehabilitation of a hypohidrotic ectodermal dysplasia patient with dental implants: a clinical report. Prosthodontic treatment in patients with ectodermal dysplasia (ED) is difficult to manage because of the oral deficiencies typical in this disorder and because afflicted individuals are quite young when they are evaluated for treatment. This clini...

Welsh, A.L.; Ede, M.; Rubenkoenig, H.L., 1961: A study of the use of phenyl-tertiary-butylamine (Wilpo) to reduce weight. Current Therapeutic Research, Clinical and Experimental 3: 281-285