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Effect of continual light deprivation and alpha-2u-globulin replacement therapy on serum concentration of gonadotropins and testicular activity in rats


, : Effect of continual light deprivation and alpha-2u-globulin replacement therapy on serum concentration of gonadotropins and testicular activity in rats. Andrologia 28(6): 309-313

Prolonged darkness caused a fall in testicular 17-beta-hydroxysteroid dehydrogenase (17-beta-HSD) activity and diminished spermatogenesis, serum levels of gonadotropins, testosterone and alpha-2u-globulin. Administration of alpha-2u-globulin at a dose of 1.5 mg rat-1 per day for 7 days after 68 days of light deprivation, reversed the 17-beta-HSD activity and serum levels of gonadotropins, testosterone and alpha-2u-globulin, while spermatogenesis was restored to normal. The animals kept in prolonged darkness for 68 days and then received saline (7 days in light-dark cycle, 14 L: 10 D), showed no significant changes of testicular activity, serum levels of gonadotropins, testosterone and alpha-2u-globulin, when compared with dark-exposed animals (68 days) receiving rabbit serum (7 days in light-dark cycle, 14 L: 10 D). These results suggest that alpha-2u-globulin plays an important role in testicular function in darkexposed rats by inducing gonadotropins and testosterone secretion.

US$19.90

PMID: 9021042

DOI: 10.1111/j.1439-0272.1996.tb02807.x


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