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Functional switching of GABAergic synapses by ryanodine receptor activation


, : Functional switching of GABAergic synapses by ryanodine receptor activation. Proceedings of the National Academy of Sciences of the United States of America 97(22): 12300-5

The role of the ryanodine receptor (RyR) in modifiability of synapses made by the basket interneurons onto the hippocampal CA1 pyramidal cells was examined in rats. Associating single-cell RyR activation with postsynaptic depolarization increased intracellular free Ca(2+) concentrations and reversed the basket interneuron-CA1 inhibitory postsynaptic potential into an excitatory postsynaptic potential. This synaptic transformation was accompanied by a shift of the reversal potential from that of chloride toward that of bicarbonate. This inhibitory postsynaptic potential-excitatory postsynaptic potential transformation was prevented by blocking RyR or carbonic anhydrase. Associated postsynaptic depolarization and RyR activation, therefore, changes GABAergic synapses from excitation filters to amplifier and, thereby, shapes information flow through the hippocampal network.

US$19.90

PMID: 11027306

DOI: 10.1073/pnas.210396697


Other references

Tanabe, M.; Kaneko, N.; Takeuchi, T., 1991: Schistosoma mansoni: higher free proline levels in the livers of infected mice. The concentration of L-hydroxyproline in the liver of ICR female mice increased rapidly during the 8th to 11th weeks of Schistosoma mansoni infection. Free L-proline concentration began to increase about the 7th week and reached its maximum at the...

Kleiman, F.; Pietrokovsky, S.; Paraense, W.Lobato.; Wisnivesky-Colli, C., 2004: Southernmost finding of Lymnaea viatrix orbigny, 1835 (Pulmonata: Lymnaeidae), intermediate host of Fasciola hepatica (Linnaeus, 1758) (Trematoda: Digenea), in urban and rural areas of Patagonia, Argentina. We report the first finding of Lymnaea viatrix south of parallel 41 masculine S, in rural and urban areas from Argentina. Ninety snails were collected during year 2000, from a concrete pond at a Public Square in El Bolsón Village, Río Negro prov...

Klimek, J.; Aleksandrowicz, Z.; Wrzolkowa, T.; Zelewski, L., 1972: The oxidative phosphorylation and electron-microscopic structure of mitochondria isolated from human term placenta. Biochemical Medicine 6(5): 426-437

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Bolterauer, H.; Tuszynski, J.A.; Unger, E., 2005: Directed binding: a novel physical mechanism that describes the directional motion of two-headed kinesin motor proteins. We propose a novel physical mechanism to describe the mode of processive propagation of two-headed kinesin motor proteins along microtubule (MT) filaments. Binding and unbinding of the kinesin heads to and from the MT filament play a crucial role...

Bray R.A., 1988: Inheritance of rust resistance in macroptilium atropurpureum. sixteen accessions of Macroptilium atropurpureum showed a range of reaction types when seedlings were inoculated with a single-urediniospore isolate of Uromyces appendiculatus (rust). Analysis of F2 families of crosses with the susceptible cv. Sir...

Walsh, S.; Pontén, A.; Fleischmann, B.K.; Jovinge, S., 2010: Cardiomyocyte cell cycle control and growth estimation in vivo--an analysis based on cardiomyocyte nuclei. Adult mammalian cardiomyocytes are traditionally viewed as being permanently withdrawn from the cell cycle. Whereas some groups have reported none, others have reported extensive mitosis in adult myocardium under steady-state conditions. Recently,...

Mahler, F.; Schlumpf, M.; Brunner, U., 1977: Long term effects of thoracic sympathectomy in digital artery occlusions. In 11 patients finger blood flow and arterial pressure were studied by using Hg strain gauges for 24 mo. following thoracic sympathectomy. After the operation (3-6 mo.) blood flow was improved in 4 of 7 male patients and in 3 of 4 females; at the...