geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

G protein-coupled receptors in gastrointestinal physiology. V. Gastrointestinal peptide signaling through tyrosine phosphorylation of focal adhesion proteins


, : G protein-coupled receptors in gastrointestinal physiology. V. Gastrointestinal peptide signaling through tyrosine phosphorylation of focal adhesion proteins. American Journal of Physiology 275(2): 77-G182

Gastrointestinal (GI) peptides (also referred to as neuropeptides or regulatory peptides), including the mammalian bombesin-like peptides gastrin and CCK, elicit the synthesis of classic second messengers (e.g., Ca2+, diacylglycerol, and cAMP) and the consequent stimulation of serine/threonine protein kinase cascades. An emerging theme in signal transduction is that these agonists also induce rapid and coordinate tyrosine phosphorylation of a set of focal adhesion proteins, including the nonreceptor tyrosine kinase p125fak and the adaptor proteins p130cas and paxillin. GI peptide-mediated induction of tyrosine phosphorylation of these focal adhesion proteins is critically dependent on the integrity of the actin cytoskeleton and on functional Rho. The purpose of this article is to review recent advances in unraveling this novel tyrosine kinase pathway(s), because it appears to play a fundamental role in the mediation of important biological effects induced by GI peptides, including cell migration and proliferation. Reprinted by permission of the publisher.

US$29.90


Other references

Colvill, K.; Bell, R.1; Roberts, T.1; Bradshaw, A., 1983: The use of open-top chambers to study the effects of air pollutants, in particular sulphur dioxide, on the growth of ryegrass Lolium perenne L. II. The long-term effect of filtering polluted urban air or adding SO2 sulphur dioxide to rural air. Environmental pollution Series A: Ecological and biological 31(1): 35-55

Abdel Aal A.; E.B.rkooky A.; Gerrits M.; Meyer H.; Schwander M.; Zaki H., 2000: Tectonic evolution of the eastern Mediterranean Basin and its significance for hydrocarbon prospectivity in the ultradeepwater of the Nile Delta. The Leading Edge (Tulsa, OK): 0, Pages 1086, 1088, 1090, 1092, 1094, 1096, 1098-1100-1102. 2000.

Roland-Heydacker, F.C.rceau-Larrival, M.; Verhille, A., 1982: Male gametophytic sterility. II. Effects of male sterility with a gametophytic determinism on the pollen phenotype in Petunia hybrida X Hort. ex Vilm. Revue de cytologie et de biologie vegetales le botaniste(1): 123-133

Petrova, N.; Michailova, P.; Bovero, S., 2000: Cytogenetic characteristics of Chironomus nuditarsis Str. (Chironomidae, Diptera) and its relationship with species from the plumosus group. Unknown

Martignoni, M.E.; Auer, C., 1957: A field test in the control of E. griseana. Describes preparations of the virus, determination of dosage on the basis of feeding experiments etc., and discusses possible reasons (e.g. the effect of ultra-violet rays on virulence) for the failure of an experiment in which 2 trees in each of...

Herzfeld, A.; Raper, S.M., 1979: Uridine kinase activities in developing, adult and neoplastic rat tissues. Uridine kinase activities were found chiefly in the soluble fractions of rat tissues. In normal adults the activities ranged from 13 munits/g in skeletal muscle to 178 munits/g in colon. Enzyme activities in several rat neoplasms were significantl...

Swanson D.A. (investigator); Byerly G.R. (investigator), 1978: Olympic-Wallowa Lineament influenced Cascade-Columbia River volcanism. U S

Getty Theodore A.; Crane Michael D., 1975: Geological collections and collectors of note; 8, An historical account of the palaeontological collections formed by R. W. Hooley (1865-1923). Newsletter of the Geological Curators Group 1(4): 170-179

Rózewicki, S.; Karasowska, K.; Zóltowski, M., 1969: Behavior of blood glucose levels after interruption of early pregnancy and after normal pregnancy. Wiadomosci Lekarskie 22(14): 1283-1287

Fakih, A.R.; Patel, A.; Bhasin, S.D., 1990: Non functioning kidney in renal cell carcinoma. Case report of an unusual cause. Indian Journal of Cancer 27(2): 123-126