geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Neutral evolution of the sex-determining gene transformer in Drosophila


, : Neutral evolution of the sex-determining gene transformer in Drosophila. Genetics 154(4): 1711-1720

The amino acid sequence of the transformer (tra) gene exhibits an extremely rapid rate of evolution among Drosophila species, although the gene performs a critical step in sex determination. These changes in amino acid sequence are the result of either natural selection or neutral evolution. To differentiate between selective and neutral causes of this evolutionary change, analyses of both intraspecific and interspecific patterns of molecular evolution of tra gene sequences are presented. Sequences of 31 tra alleles were obtained from Drosophila americana. Many replacement and silent nucleotide variants are present among the alleles; however, the distribution of this sequence variation is consistent with neutral evolution. Sequence evolution was also examined among six species representative of the genus Drosophila. For most lineages and most regions of the gene, both silent and replacement substitutions have accumulated in a constant clock-like manner. In exon 3 of D. virilis and D. americana we find evidence for an elevated rate of nonsynonymous substitution, but no statistical support for a greater rate of nonsynonymous relative to synonymous substitutions. Both levels of analysis of the tra sequence suggest that, although the gene is evolving at a rapid pace, these changes are neutral in function. Reprinted by permission of the publisher.

US$29.90

PMID: 10747064


Other references

Fezer, K.D.; Ross, A.F., 1959: Assay of alfalfa mosaic virus activity. Of 11 varieties of Phaseolus vulgaris screened as local-lesion test plants for alfalfa mosaic virus activity, Bountiful, Tendergreen, Red Kidney, and Yellow Eye were the most satisfactory. Virus extracts prepared by grinding source-plant (Nicotlan...

Strandberg, M.T.; Scott-Fordsmand, J.J., 2002: Field effects of simazine at lower trophic levels--a review. Simazine is a triazine herbicide used in agriculture, pot-plant and tree production. The total concentrations (dissolved + adsorbed) in soil depend on the application rate, for example an application rate of 1500 g simazine/ha will result in appro...

Birot Pierre, 1951: Sur la desintegration granulaire des roches cristallines. By testing the rate of penetration of methylene blue in many rock samples before and after daily temperature and humidity changes for six months, it was found that the rocks most resistant to the effects of climate are those which absorb water mos...

Jenny,R., 2008: Otoglossum chiriquense a beautiful and rare orchid. The taxonomy and morphology of <i>Otoglossum chiriquense</i> are discussed. Illustrations are also provided.

Sheen, V.L.; Ohaegbulam, C.; Rencus, T.; Tandon, D., 2010: Gabapentin-induced exacerbation of myasthenia gravis. Muscle & Nerve 42(1): 149-149

Honma, M.; Kubota, Y.; Matsumoto, M., 1972: Case of breast cancer with esophageal metastasis causing dysphagia. Gan No Rinsho. Japan Journal of Cancer Clinics 18(6): 419-422

Marshall, E., 1979: Carcinogens in scotch. A National Science Foundation report states that a carcinogen known as N-nitrosodimethylamine (NDMA) has been discovered in 6 brands of Scotch whiskey and 18 brands of beer. NDMA causes cancer in nearly every laboratory animal tested. German and A...

Estes, S.D.; Stoler, D.L.; Anderson, G.R., 1995: Normal fibroblasts induce the C/EBPb and ATF-4 bZIP transcription factors in response to anoxia. Experimental Cell Research 220: 54

Hengeveld, Rob, 2002: Methodology going astray in population biology. This paper analyses the broad methodological structure of population-biological theorising. In it, I show that the distinction between initial exploratory, hypothesis-generating research and the subsequent process-reconstructing, hypothesis-testin...

Griffiths, D.W., 1979: The inhibition of digestive enzymes by field bean testa. Seed coat extracts prepared by aqueous extraction of white and purple-flowering varieties of Vicia faba L. were tested for their inhibitory activity towards trypsin and other enzymes. Extracts of the purple-flowering variety had up to 50% trypsin...