geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Positive selection of self-MHC-reactive T cells by individual peptide-MHC class II complexes


, : Positive selection of self-MHC-reactive T cells by individual peptide-MHC class II complexes. Proceedings of the National Academy of Sciences of the United States of America 99(10): 6937-6942

If T cells require specific interactions with MHC-bound peptides during positive selection, then the specificities of T cells selected by one peptide should be distinct from those selected by another. We have examined positive selection of CD4 T cells in four strains of mice, each overexpressing a different peptide-1-A(b)(A(b)) complex. We show that a subset of CD4 T cells is selected by the overexpressed peptide and that the specificities of the CD4 T cells, as measured by reactivity to wild-type antigen-presenting cells, vary greatly depending on which peptide is overexpressed. These differences in specificity are mediated through positive selection not negative selection. Each of the four peptide-A(b) complexes appears to adopt a different conformation, and these differences correlate with the differences in reactivity. Our results suggest that individual peptide-MHC complexes positively select different subsets of self-MHC-reactive T cells and that the conformation of the peptide-MHC complex may contribute to this process.

US$19.90

PMID: 12011451

DOI: 10.1073/pnas.102645699


Other references

Hohenberger, P.; Bida, B.; Schlag, P.M., 1996: Alteration of tissue oxygen partial pressure during isolated, hyperthermic limb perfusion with cytostatic drugs or recombinant human tumor necrosis factor alpha combined with melphalan. Strahlentherapie und Onkologie 172 Suppl 2: 14-15

Lee, Y-Ah.; Kang, S-Goo.; Song, S-Wook.; Rho, J-Seung.; Kim, E-Kyung., 2016: Association between metabolic syndrome, smoking status and coronary artery calcification. Coronary artery calcification (CAC), an indicator of coronary artery stenosis, is an independent risk factor of ischemic heart disease. Smoking increases the risk of metabolic syndrome (MS) and cardiovascular disease. Almost no previous studies ha...

Anonymous, 1985: The sedimentary conditions of the 3rd member of the Shahejie Formation (Paleogene) in Huanghua Depression, Hebei Province. 48 species referred to 15 genera of ostracod fossils from the 3rd member of the Shahejie Formation (Paleogene) in the Huanghua depression have been identified. The ecology of the ostracod fossils indicates that most of them lived in environments o...

Bopp, R.J.; Breau, A.P.; Faulkinbury, T.J.; Heath, P.C.; Miller, C.; Stephan, E.A.; Weigel, L.O.; Wong, D.T., 1994: The rearrangement of duloxetine under mineral acid conditions. Abstracts of Papers American Chemical Society 207(1-2): ORGN 111

Schulz, Peggie, 1959: Hybridizing African violets. A discussion of the technique, and suggestions of desirable parents to use in breeding.

Hou YiLong; Zhang KaiChun; H.W.nYu; W.L.Ping; Lin Ke; Yin ShuPing, 2002: Detection of several RNA viruses in fruit trees by RT-PCR. The virus indicator plants R12740-7A, Virginia Crab, Radiant [apples], GF305 [?peach] and Chenopodium quinoa were used to optimize the RT-PCR detection systems for apple chlorotic leaf spot virus, apple stem grooving virus, apple stem pitting viru...

Brown, D.A.; Bruce, M.E.; Fraser, J.R., 2003: Comparison of the neuropathological characteristics of bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease in mice. Bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (vCJD) belong to a group of diseases called the transmissible spongiform encephalopathies (TSEs). Transmission studies in inbred mice (strain typing) provided overwhelmin...

Farnoush A.; Nuki K., 1985: Labeling of gingival and dermal mast cells with and without degranulation by 48 80 4 methoxy n methylbenzeneethanamine formaldehyde product. The mode of proliferation of mast cells in non-inflamed gingiva and skin of Swiss Webster mice was investigated. Single and multiple pulses of 3H-thymidine and autoradiographic procedures to detect DNA synthesis were used in conjunction with selec...

Cherstvy, A.G., 2012: Critical polyelectrolyte adsorption under confinement: planar slit, cylindrical pore, and spherical cavity. We explore the properties of adsorption of flexible polyelectrolyte chains in confined spaces between the oppositely charged surfaces in three basic geometries. A method of approximate uniformly valid solutions for the Green function equation for...

Vasta, M.C.; Verdone, A.M.; Russo, A.; L.T.rra, S., 2004: Evaluation of chromotropic traps attractiveness for monitoring flies in dairy industries Valutazione dellattrattivita di trappole cromotropiche per il monitoraggio di ditteri nellindustria lattiero-casearia. Atti del Congresso Nazionale Italiano di Entomologia, 192: 981-985