+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The parathyroid hormone/parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation

, : The parathyroid hormone/parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation. Proceedings of the National Academy of Sciences of the United States of America 95(22): 13030-13035, Oct 27

During vertebrate limb development, growth plate chondrocytes undergo temporally and spatially coordinated differentiation that is necessary for proper morphogenesis. Parathyroid hormone-related peptide (PTHrP), its receptor, the PTH/PTHrP receptor, and Indian hedgehog are implicated in the regulation of chondrocyte differentiation, but the specific cellular targets of these molecules and specific cellular interactions involved have not been defined. Here we generated chimeric mice containing both wild-type and PTH/PTHrP receptor (-/-) cells, and analyzed cell-cell interactions in the growth plate in vivo. Abnormal differentiation of mutant cells shows that PTHrP directly signals to the PTH/PTHrP receptor on proliferating chondrocytes to slow their differentiation. The presence of ectopically differentiated mutant chondrocytes activates the Indian hedgehog/PTHrP axis and slows differentiation of wild-type chondrocytes. Moreover, abnormal chondrocyte differentiation affects mineralization of cartilaginous matrix in a non-cell autonomous fashion; matrix mineralization requires a critical mass of adjacent ectopic hypertrophic chondrocytes. Further, ectopic hypertrophic chondrocytes are associated with ectopic bone collars in adjacent perichondrium. Thus, the PTH/PTHrP receptor directly controls the pace and synchrony of chondrocyte differentiation and thereby coordinates development of the growth plate and adjacent bone.


PMID: 9789035

DOI: 10.1073/pnas.95.22.13030

Other references

Olsen, A.K.; Mayock, P.P., 1948: Causalgia, with report of a case. Guthrie Clinic Bulletin 18(2): 48-51

D.W.syl; A.H.szowski, 2012: First isolation of ESBL-producing Salmonella and emergence of multiresistant Salmonella Kentucky in turkey in Poland. The first CTX-M-producing Salmonella was described in primary animal production in Poland, due to the antimicrobial resistance monitoring and control program introduced in turkeys. It was associated with the outbreak of multiresistant Salmonella K...

Li, H.; Wang, S-xiang., 2011: Improvement of hypertension and LVH in maintenance hemodialysis patients treated with sustained-release isosorbide mononitrate. Hypertension and left ventricular hypertrophy (LVH) are independent predictors of morbidity and mortality in maintenance hemodialysis (MHD) patients. The level of serum asymmetric dimethylarginine (ADMA) is increased in MHD patients, which is a ki...

Zubairu, A.M.; Wright, N.B.; Wynn, R.F., 2001: Bilateral subdural effusions related to disease activity in familial hemophagocytic lymphohistiocytosis in an 8-month-old infant. An 8-month-old girl had classic features of hemophagocytic lymphohistiocytosis (HLH). A presumptive diagnosis of familial hemophagocytic lymphohistiocytosis was made on the basis of her age and the presence of parental consanguinity. In view of ab...

Misiak, Błażej.; Beszłej, J.Aleksander.; Kotowicz, K.; Szewczuk-Bogusławska, M.; Samochowiec, J.; Kucharska-Mazur, J.; Frydecka, D., 2017: Cytokine alterations and cognitive impairment in major depressive disorder: From putative mechanisms to novel treatment targets. Overwhelming evidence indicates the involvement of immune-inflammatory processes in the pathophysiology of major depressive disorder (MDD). Peripheral cytokine alterations serve as one of most consistently reported indices of subthreshold inflamma...

Boudarel, P.; Kobierzycki, E., 1995: Observation de chasse du faucon hobereau (Falco subbuteo) a l'etage nival dans les Pyrenees. Alauda 63(1): 42

Wagner, S.D.; Hauschild, C.; Wang, C.H., 1999: Early activation by B cells producing multiple-antibody isotypes in the small intestine. FASEB Journal 13(5 PART 2): A997, March 15

Wu, Y.; Zhang, B.; Sun, D., 1996: Ecological characteristics of Penaeus chinensis resources in Jiaozhou Bay. Studia: 131-134

Semmler, U., 1979: Significance of semiquantitative joint scintigraphy for the early diagnosis of primary arthritis. Rheumatology and Rehabilitation Suppl: 34-35

Pupka, A.; Skóra, J.; Kałuza, G.; Szyber, P., 2004: The detection of Chlamydia pneumoniae in aneurysm of abdominal aorta and in normal aortic wall of organ donors. Sixty patients underwent surgery due to abdominal aortic aneurysms; the group included 30 patients with asymptomatic aneurysm and 30 with ruptured aneurysm. A control group comprised 30 organ donors. Surgical specimens derived from aneurysm or aor...