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The post-translational incorporation of arginine into a beta-amyloid peptide increases the probability of alpha-helix formation

, : The post-translational incorporation of arginine into a beta-amyloid peptide increases the probability of alpha-helix formation. Neuroreport 7(1): 326-328

The beta-amyloid peptide (beta-AP-1-40) inhibited the in vitro post-translational incorporation of (14C)arginine at the N-terminus of brain soluble proteins and was labelled by the incorporation of (14C)arginine. Addition of arginine at the N-terminal position of beta-AP-1-40 is predicted to increase the probability of an alpha-helix structure being formed on the first residues with a higher hydrophilic characteristic, increasing the possibility of these residues being exposed to the aqueous environment. Unmodified beta-AP-140 has a low alpha-helix content and a higher probability of beta-turn formation. Accumulation of beta-AP-1-40 in Alzheimer's disease may therefore be due to a reduced arginylation reaction and consequently to a decrease in its normal degradation by the ubiquitin pathway.


PMID: 8742481

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