+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The protective role of endogenous cytokines in host resistance against an intragastric infection with Listeria monocytogenes in mice

, : The protective role of endogenous cytokines in host resistance against an intragastric infection with Listeria monocytogenes in mice. FEMS Immunology & Medical Microbiology 16(3-4): 291-298

It has been demonstrated that endogenous cytokines including gamma-interferon (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) play a protective role but that IL-4 plays a detrimental role in systemic Listeria monocytogenes infection in mice. The diverse roles of IL-10 have been reported in antilisterial resistance. In this paper, we studied the role of endogenous cytokines in host resistance against an intragastric infection with L. monocytogenes in mice. The expression of cytokine mRNAs including IFN-gamma, TNF-alpha, IL-4, IL-6, or IL-10, which were amplified by reverse transcription-PCR, was observed in intestinal intraepithelial lymphocytes irrespective of L. monocytogenes infection. Increased numbers of L. monocytogenes were detected in the ileal contents of infected mice which received monoclonal antibodies (mAbs) against IFN-gamma, TNF-alpha, IL-4, IL-6, or IL-10. By contrast, mAbs against IL-4 or IL-6 showed little effect on the growth of L. monocytogenes in the mesenteric lymph nodes (MLNs), spleen, and liver, but anti-IFN-gamma mAb and anti-TNF-alpha mAb suppressed the defense in these organs. Anti-IL-10 mAb enhanced bacterial elimination from the MLNs but not from the spleen or liver. These results suggest that the role of endogenous cytokines may differ between systemic and intestinal defenses.


PMID: 9116648

DOI: 10.1111/j.1574-695x.1996.tb00148.x

Other references

Christensen, J.; Kjeldsen, M.J.el; Andersen, H.; Friis, M.L.ue; Sidenius, P., 2003: Gender difference in idiopathic generalized epilepsy. Epilepsia 44(Supplement 9): 286-287

James, A.-L.R.ulet, N., T., 2007: Investigating hydrologic connectivity and its association with threshold change in runoff response in a temperate forested watershed. Hydrological studies across varied climatic and physiographic regions have observed small changes in the 'states of wetness'; based on average soil moisture, can lead to dramatic changes in the amount of water delivered to the stream cha...

Johnson, L.L.; Sayles, P.C., 1998: Interleukin-12, dendritic cells, and the initiation of host-protective mechanisms against Toxoplasma gondii. Journal of Experimental Medicine 186(11): 1799-1802

Ullah, S.; Shah, S.Humayun.; Rehman, A.Ur.; Kamal, A.; Begum, N., 2002: Tuberculous lymphadenitis in Afghan refugees. Tuberculosis is a disease of poor countries. The war-stricken Afghan refugees, owing to abject poverty, illiteracy, lack of social awareness and poor hygienic conditions, are highly susceptible to tuberculosis. This study was conducted to assess t...

Oviasu V.O., 1977: Diurnal variation of oral glucose tolerance in nigerians. Nigerian Medical Journal 7(2): 158-161

Topcu, Çi?dem; Y?ld?r?m, A.; Erdur-Baker, Özgür, 2013: Cyber Bullying Schools What do Turkish Adolescents Think?. Cyber bullying is an emerging form of peer bullying, becoming prominent especially over the past decade. The aim of this study was to investigate through interviews the perceptions of Turkish high school students about cyber bullying. The sample c...

Benoit P.; Verin M.; Michelet A., 1970: Functional results from the treatment of the fracture of lower part of orbita. Acta Stomatologica Belgica 67(1): 146

Wang, X.; Ma, C.; Li, P.; Zhao, F.; Bi, L., 2017: Effects of iguratimod on the levels of circulating regulators of bone remodeling and bone remodeling markers in patients with rheumatoid arthritis. This study aims to investigate the effect of iguratimod, a novel disease-modifying antirheumatic drug, alone or combined with methotrexate (MTX), on the serum levels of regulators of bone remodeling (receptor activator of nuclear factor-κB ligand...

Rittenhouse S.E.; Sasson J.P., 1985: Mass changes in myo inositol trisphosphate in human platelets stimulated by thrombin inhibitory effects of phorbol esters. Myoinositol trisphosphate (IP3) is formed when phosphatidylinositol-4,5-bisphosphate (PIP2) is hydrolyzed by phospholipase C. At .mu.M concentrations, IP3 is a stimulus for Ca2+ release in both platelet membranes and various permeabilized cells. A...

Lozano, R.D.; Palmer, D.A., 1967: The additivity of large-field colour matching functions. The color matching functions of 4 observers were measured on the National Physical Laboratory's trichromator with a 10[degree] field. The tristimulus values of 20 test colors were calculated from the functions for comparison with measurements...