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C-tocopherol and its major metabolite, in contrast to a tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells

, : C-tocopherol and its major metabolite, in contrast to a tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells. Proceedings of the National Academy of Sciences of the United States of America 97(21): 494-9

The effects of c-tocopherol (cT) on the inflammatory response in macrophages and human epithelial cells were investigated. Overall, the findings showed that, at physiological concentrations, both cT and its major hydrophilic metabolite 2,7,8-trimethyl-2-(b-carboxyethyl)-6-hydroxychroman (c-CHEC) were effective in inhibiting cyclooxygenase-2 activity in intact cells. Thus, cT and c-CHEC may possess anti-inflammatory activity, and at physiological concentrations cT may be important in human disease prevention.


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