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(R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes

, : (R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes. Drug Metabolism and Disposition: the Biological Fate of Chemicals 28(10): 1187-1191

Fluoxetine is one of the most widely prescribed selective serotonin reuptake inhibitors (SSRIs) that is marketed worldwide. However, details of its human hepatic metabolism have been speculative and incomplete, possibly due to the sensitivity of analytical techniques and selectivity of specific in vitro probes and reagents used.


PMID: 10997938

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