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(S)-N-(1-(3-Morpholin-4-ylphenyl)ethyl)-3-phenylacrylamide: An orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine


, : (S)-N-(1-(3-Morpholin-4-ylphenyl)ethyl)-3-phenylacrylamide: An orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine. Journal of Medicinal Chemistry 46(15): 3197-3200

(S)-N-(1-(3-Morpholin-4-ylphenyl)ethyl)-3-phenylacrylamide (2) was synthesized as an orally bioavailable KCNQ2 potassium channel opener.

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