+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

1.9 ANG resolution crystal structure of the Saccharomyces cerevisiae Ran-binding protein Mog1p

, : 1.9 ANG resolution crystal structure of the Saccharomyces cerevisiae Ran-binding protein Mog1p. Journal of Molecular Biology 299(1): 213-223, 26 May

The 1.9 ANG resolution X-ray crystal structure of Ran-binding protein Mog1p shows that it has a unique fold based on a six-stranded antiparallel beta-sheet backed on both sides by an extensive alpha-helix. The topology of some elements of Mog1p secondary structure resemble a portion of nuclear transport factor 2 (NTF2), but the hydrophobic cavity and surrounding negatively charged residues that are important in the NTF2-RanGDP interaction are not conserved in Mog1p. In addition to binding RanGTP, Mog1p forms a 1:1 complex with RanGDP and so binds Ran independent of its nucleotide state. Mog1p and NTF2 compete for binding to RanGDP indicating that their binding sites on RanGDP are sufficiently close to prevent both proteins binding simultaneously. Although there may be some overlap between the Mog1p and NTF2 binding sites on RanGDP, these sites are not identical. Sequence analysis of Mog1p homologues from Schizosaccharomyces pombe, human, and Caenorhabditis elegans in the context of the Mog1p crystal structure indicates the presence of a cluster of highly conserved surface residues consistent with an interaction site for Ran.


Other references

Fatimi, S.H.; Schuuring, M.J.; Sheikh, S., 2007: Rare relapsed extrapulmonary hydatid disease. Hydatid cysts are rarely seen at the extrapulmonary sites. We report relapsed hydatid cysts with abdominal origin in a 25 years old woman. Over 1000 Hydatid cysts were removed through right posterolateral thoracotomy without any complications. Onl...

Jimerson D.C.; Gordon E.K.; Post R.M.; Goodwin F.K., 1975: Central noradrenergic function in man vanillyl mandelic acid in cerebro spinal fluid. Brain Research 99(2): 434-439

Eliah, E., 2002: In Uganda, elders work with the UN to safeguard women's health. This article reports on the 1998 UN population award that was given to Uganda's Sabiny Elders Association (SEA) for its work in combatting female circumcision (FC) among the Sabiny people in Eastern Uganda's Kapchorwa district. The elder...

Mazikov, SA.; Menzikova, OV., 2002: Effect of activators and blockers of ligand-regulated ion channels on the activity of the Cl--stimulated Mg-ATPase of the plasma membrane fraction from bream brain (Abramis brama L.). Biokhimiya. Fevral; 672: 278-285

Costello, P.; Berek, B.; Kobs, A.; Thew, P., 1999: I'm from the Joint Commission and I'm here to help you ... roundtable discussion. Materials Management in Health Care 8(7): 44, 46-44, 46

Anonymous, 1988: Safety of blood products for haemophilia patients. Lancet 2(8607): 409-409

Jones Randall A., 1986: Phosphorus concentrations in the sediments of eight Oregon lakes; a comparison of content in relation to watershed morphometry, and trophic status. Proceedings of the Oregon Academy of Science: ages 22. 1986.

Takagi, K., 2000: Management of metastatic bone disease in orthopedics. Journal of Orthopaedic Science 5(3): 183-184

Schmidt, K.G.; Dick, B.; von Rückmann, A.; Pillunat, L.E., 1997: Ocular pulse amplitude and local carbonic anhydrase inhibition. Ocular perfusion is increasingly being discussed in the pathogenesis of glaucoma. The present study was designed to investigate ocular pulse amplitude (OPA) in primary open-angle glaucoma (POAG) patients with elevated intraocular pressure (HTG) an...

Phillips, R.W.; Miller, J.C., 1938: Conference on artificial insemination. 31st Ann. Meet. Amer. Soc. Anim. Prod. PROCEEDINGS and discussion are briefly reported. Berliner discussed work on pigs in Mississippi and reported successful use of pregnant mare serum on gilts failing to come on heat; Phillips, a continuation of the work on long range shipment of ram...