geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

5-HT2A receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner


, : 5-HT2A receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner. Brain Research 947(2): 157-165, 30 August

Combined serotonin (5-HT)(2A) and dopamine (DA) D(2) blockade has been shown to contribute to the ability of atypical antipsychotic drugs (APDs) to increase DA release in rat medial prefrontal cortex (mPFC). We provide additional support for this hypothesis by examining the effect of the selective 5-HT(2A) antagonist M100907 plus haloperidol, a potent D(2) antagonist APD, on DA release in the mPFC and nucleus accumbens (NAC). Haloperidol (0.01-1.0 mg/kg) produced an inverted U-shaped increase in DA release in the mPFC, with a significant increase only at 0.1 mg/kg. Haloperidol (0.1 and 1.0 mg/kg) significantly increased DA release in the NAC. M100907 (0.1 mg/kg) by itself had no effect on DA release in either region. This dose of M100907 potentiated the ability of low (0.01-0.1 mg/kg), but not high dose (0.3-1.0 mg/kg) haloperidol to increase mPFC DA release, whereas it abolished the effect of both 0.1 and 1.0 mg/kg haloperidol on NAC DA release. These results suggest that the relatively higher ratio of 5-HT(2A) to D(2) antagonism may contribute to the potentiation of haloperidol-induced mPFC DA release, whereas 5-HT(2A) antagonism can diminish haloperidol-induced NAC DA release, even when combined with extensive D(2) antagonism, which may not be synergistic with 5-HT(2A) antagonism in the mPFC.

US$19.90

PMID: 12176156

DOI: 10.1016/s0006-8993(02)02620-3


Other references

Lee, E.; Zhang, T.; Hu, M.; Luo, T., 2016: Thermal boundary conductance enhancement using experimentally achievable nanostructured interfaces - analytical study combined with molecular dynamics simulation. Interfacial thermal resistance presents great challenges to the thermal management of modern electronics. In this work, we perform an analytical study to enhance the thermal boundary conductance (TBC) of nanostructured interfaces with square-shape...

Cochran, M.D.; Shih, M.F.; Macconnell, W.P.; Macdonald, R.D., 1998: Recombinant infectious bovine rhinotrocheitis virus. Official Gazette of the United States Patent & Trademark Office Patents 121(2): 1654-1655, June 9

Roy, D.; Pathak, D.N.; Singh, R., 1983: Effect of centrophenoxine on the antioxidative enzymes in various regions of the aging rat brain. This study investigated the effect (in vivo) of centrophenoxine (Helfergin) on the activity of antioxidant enzymes (glutathione peroxidase GSH-PER, glutathione reductase GSSG-RED, superoxide dismutase SOD and catalase) in subcellular fractions fro...

Davies, N.B.; Hartley, I.R.; Hatchwell, B.J.; Langmore, N.E., 1996: Female control of copulations to maximize male help: A comparison of polygynandrous alpine accentors, Prunella collaris, and dunnocks, P. modularis. Alpine accentors and dunnocks bred in polygynandrous groups in which two or more unrelated males shared two or more females. In both species, a female solicited actively to both alpha and subordinate males whereas an alpha male attempted to guard...

Crocombe, L., 2016: Three Years of Water Fluoridation May Lead to a Decrease in Dental Caries Prevalence and Dental Caries Experience in a Community With High Caries Rates. Journal of Evidence-Based Dental Practice 15(3): 124-125

Ceccaldi, P.F., 1953: Hormone determination in test of adrenal cortex function. France Medecine 16(1): 27-28

Belles, X.; Ventura, J., 1981: Effects of several juvenoids against pupae of Conomorium patulum (Walker). (Hymenoptera, Pteromalidae). Scientific Papers of the Institute of Organic and Physical Chemistry of Wroclaw Technical University, 835-840 No. 22 2

Sakai, Y., 1980: Puncture biopsy. Rinsho Byori. Japanese Journal of Clinical Pathology Suppl: 81-85

Zulkifli, S.N.; Yun-Low, W.; Yusof, K., 1999: Role of schools of public health on maternal and child health programmes in the Asia-Pacific region. This paper assessed the role of public health schools on maternal and child health programmes in the Asia Pacific region. Economic development and its associated effects, particularly in the ASEAN countries, for example, migrant labour, ageing, en...

Logan, Samuel H., 1964: Economics of scale in California cattle-slaughtering plants. Costs were synthesized for eight model plants using: (1) conventional or bed-type slaughtering, and (2) intermittent and continuous-flow on-the-rail dressing. Designed capacities of the plants varied from 17 to 120 head per hour. Average long-run...