geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A chronic hypercoagulable state in patients with beta-thalassaemia major is already present in childhood


, : A chronic hypercoagulable state in patients with beta-thalassaemia major is already present in childhood. British Journal of Haematology 107(4): 739-746

A higher than normal incidence of thromboembolic events has been observed in adult patients with beta-thalassaemia major (TM) and certain haemostatic anomalies found in these patients suggest the existence of a chronic hypercoagulable state. Thalassaemic red blood cells (RBC) were demonstrated to facilitate thrombin formation due to altered asymmetry of the membrane phospholipids with enhanced exposure of phosphatidylserine. Since RBC anomalies exist in thalassaemia from the first months of life, we studied markers of hypercoagulability and thrombophilia in 36 adult patients (range 19-38 years) and 26 children (range 2-18 years) with beta-TM. All the patients were in steady state and none had experienced clinical signs or symptoms of thrombosis. Highly elevated urinary levels of 11-dehydro-thromboxane B2 and significantly elevated plasma levels of thrombin-antithrombin III (TAT) complexes were observed to the same extent in TM children and adults. The levels of factor II were decreased while factors V, VII + X and plasminogen were within the normal range. The natural coagulation inhibitors, protein C (PC) and protein S (PS) were significantly decreased in all TM patients investigated, regardless of age, but the PS binding protein (C4bBP) and antithrombin III levels were normal. The frequency of other thrombophilic mutations was not increased. Thus, a chronic hypercoagulable state already exists in thalassaemia in childhood and may contribute to the cardiac and pulmonary anomalies and the thrombotic events which occur later.

US$29.90

PMID: 10606878


Other references

Wirth, P.; Nowicki, M.; Helm, T.N.; Lin, L., 2016: Friable nodule on the back. Cutis 95(3): E8-11

Wegner, H.C., 1979: Patenting the products of genetic engineering. Biotechnology Letters 1(3): 145-150

Naidenow, W., 1963: Des Zooplankton der Donau Tor dem bulgarischen Ufer. Izvestiya na Zoologicheskiya lnstitut Sofiya, 13: 147-158

Ghazali, N.J.; Cox, F.R., 1981: Effect of temperature on soybean growth and manganese accumulation. In sol. culture experiments, 2-wk-old soyabean seedlings which had been grown in a sol. lacking Mn and were showing Mn deficiency symptoms were grown at all combinations of 18/14, 22/18, 26/22 or 30/26 deg C day/night temp. and 0.2, 2, 10, 20, 200...

Xu-Luo-Nan; Liang-Gui-Zhao; Mei-Hu; Zheng-Huai-Li; Zhou-Peng; Wang-Juan; Li-Zhi-Liang, 2008: 3D-QSAR study of 200 aromatic compounds using three-dimensional holographic vector of atomic interaction field3D-HoVAIF. A newly developed three-dimensional holographic vector of atomic interaction field 3D-HoVAIF)was used to describe the chemical structure of 200 aromatic compounds with toxic effect on Tetrahymena pyriformis. After the structural characterization,...

Mountjoy, N.J.; Seekamp, E.; Davenport, M.A.; Whiles, M.R., 2014: The best laid plans: community-based natural resource management (CBNRM) group capacity and planning success. As community-based natural resource management (CBNRM) increases in popularity, the question of the capacity of such groups to successfully manage natural resources becomes increasingly relevant. However, few studies have quantifiably analyzed how...

Schwarz, R.; Tänzler, D.; Ihling, C.H.; Sinz, A., 2016: Monitoring Solution Structures of Peroxisome Proliferator-Activated Receptor β/δ upon Ligand Binding. Peroxisome proliferator-activated receptors (PPARs) have been intensively studied as drug targets to treat type 2 diabetes, lipid disorders, and metabolic syndrome. This study is part of our ongoing efforts to map conformational changes in PPARs i...

Offori, E.D.; Dorner, P.A., 1975: Techniques for rearing Glossina tachinoides Westw. Techniques developed at the Seibersdorf Laboratory, Austria, for the rearing of Glossina tachinoides Westw. are described, and the performance of a colony maintained for 12 months is discussed. The flies were maintained at 24.5-26 deg C and 72-75%...

Rath, J.J.G.; Koppen, H.; Treurniet, F.E.E.; Comans, E.F.I.; Wirtz, P.W., 2012: Reversible posterior leucoencephalopathy syndrome mimicking low-grade glioma: differentiation by positron emission tomography. Clinical Neurology and Neurosurgery 113(9): 785-787

Chiong, A.T.; Fitz, H.Gh.G.S., 1957: Glomus jugulare tumor; case report (chemodectoma or nonchromaffin paraganglionoma). Journal of the Philippine Medical Association 33(3): 171-174