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A double-blind comparison of desipramine and placebo in children and adolescents with chronic tic disorder and comorbid attention-deficit/hyperactivity disorder

, : A double-blind comparison of desipramine and placebo in children and adolescents with chronic tic disorder and comorbid attention-deficit/hyperactivity disorder. Archives of General Psychiatry 59(7): 649-656

Background: Currently, there is no consensus on the best therapeutic approach to chronic tic disorders and comorbid attention-deficit/hyperactivity disorder (ADHD). To address this issue, we evaluated the tolerability and efficacy of the noradrenergic tricyclic antidepressant desipramine hydrochloride in the treatment of children and adolescents with chronic tic disorders and comorbid ADHD. Methods: Forty-one children and adolescents with chronic tic disorders, including Tourette disorder and comorbid ADHD, were studied in a 6-week, double-blind, placebo-controlled, parallel trial. Desipramine was titrated weekly up to 3.5 mg/kg per day. We rated ADHD and tic symptoms weekly and monitored adverse effects, laboratory findings, and cardiovascular parameters. Results: Treatment with desipramine (mean total daily dose, 3.4 mg/kg per day) was well tolerated without meaningful adverse effects. Desipramine significantly reduced core symptoms of ADHD (ADHD Rating Scale; 42% decrease from baseline relative to placebo, P<.001), with equal response in inattentive symptoms and hyperactive/impulsive symptoms (P<.001 for both). The ADHD response rate was robust (71% vs 0%; desipramine vs placebo, P<.001). Likewise, desipramine significantly reduced tic symptoms (Yale Global Tic Severity Scale; 30% decrease from baseline relative to placebo, P<.001), with equal response in motor and phonic tic symptoms (P<.01 for both). The tic response rate was substantial (58% vs 5%; desipramine vs placebo, P<.001). There were small but statistically significant differences between desipramine and placebo in heart rate and blood pressure. Conclusions: Treatment with desipramine was well tolerated and was associated with robust clinically significant reductions in tic and ADHD symptoms in children and adolescents with chronic tic disorders and ADHD diagnoses.


PMID: 12090818

DOI: 10.1001/archpsyc.59.7.649

Other references

Frantz, W.E., 1984: Reflections on ten years experience with a tri-county mental health center. Alabama Medicine 53(12): 13-15

Rosso, O.A.; Blanco, S.; Creso, J.; Figliola, A.; Rabinowicz, R., 1999: Nonlinear dynamic analysis of wavelet filtered Grand Mal epileptic records. Epilepsia 40(SUPPL 2): 16

Afshani, P.; Littenberg, G.D.; Wollman, J.; Kaplowitz, N., 1978: Significance of microscopic cholangitis in alcoholic liver disease. Marked biochemical cholestasis mimicking extrahepatic obstruction may occur in alcoholic liver disease. Twenty-three consecutive hyperbilirubinemic alcoholics who underwent liver biopsy were studied. Comparison of the clinical, laboratory, and his...

Mizunov, G.P., 1958: The morphological and biological features of perennial onion. Some features of Welsh onion, chives, many-tiered, Pskem, milky-flower, Altai, and Aflatun onion are described.

Burkert, W.; Hübner, K.; Schlesinger, L., 1974: Correlations between preoperative finding, surgical finding, and surgical result in lumbar intervertebral disk prolapse. Zentralblatt für Chirurgie 99(45): 1409-1414

Blasco Patiño, F.; Pérez Maestu, R.; Martínez López de Letona, J.; Jiménez, A.I.; García Navarro, M.J., 2009: Study of the conpsumption of innapropiate medicaments in elder hospitalized in the Internal Medicine Service. The elderly patients are characterized by the high degree of polymedication. This factor is the most important in the appearance of adverse effects (EAD). The study of the medicaments helps to establish which are inappropriate and therefore they m...

Perseke, C., 1982: Composition of acid rain in the Federal Republic of Germany--spatial and temporal variations during the period 1979-1981. Deposition of atmospheric pollutants: proceedings of a colloquim held at Oberursel Taunus West Germany 9-11 November 1981 edited by HW Georgii and J Pankrath: 6

Olsen Stanley J., 1979: Archaeologically, what constitutes an early domestic animal?. Advances in Archaeological Method and Theory: ges 175-197. 1979.

Lavery H.A.; Connolly J.H.; Russell J.D., 1986: Incidence of herpes genitalis in northern ireland 1973 1983 and herpes simplex types 1 and 2 isolated 1982 1984. During 1973-83 there was a pronounced rise in the number of new cases of herpes genitalis in Northern Ireland. This study of 127 patients with herpes genitalis shows that 30% had herpes simplex virus type 1 (HSV 1) and 70% had herpes simplex virus...

Nagendran, C.; Arekal, G., 1983: Studies on Indian Podostemaceae. Bulletin of the Botanical Survey of Indiaub 1983) 23(3-4): 228-234