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A new look on the position of the oxygen equilibrium curve of human adult hemoglobin at rest and during exercise with special reference to the effectiveness of the Bohr shift


, : A new look on the position of the oxygen equilibrium curve of human adult hemoglobin at rest and during exercise with special reference to the effectiveness of the Bohr shift. Zoological Science (Tokyo) 18(7): 905-908, September

The position of oxygen equilibrium curve (OEC) for human adult Hb at rest is optimized with respect to the effectiveness of the Bohr shift which is measured by the change in O2 saturation at a venous O2 pressure of 40 torr per unit change in partial pressure of O2 at half saturation (dS(40)/dP50). The effectiveness of the Bohr shift at the physiological P50 of 27 torr depends on the cooperativity of O2 binding calculated by the Hill coefficient n, being maximized at n = 4. The effectiveness of the Bohr shift during exercise, which was expressed as dS(PvO2)/dP50, was the highest at the PvO2 (venous O2 pressure) of 28 torr. The effectiveness of the Bohr shift at PvO2 of 28 torr increased with increases n value (n value ranged from 2.65 to 3.27), while below PvO2 of 15 torr the opposite was true. As a whole, the position of the OEC of human adult Hb at rest is optimized with respect to the effectiveness of the Bohr shift while the efficiency of O2 delivery is moderately maintained. On the other hand, during exercise the position of the OEC is adjusted to make the efficiency of O2 delivery at high levels while the effectiveness of the Bohr shift is maintained at the same level as that at rest.

US$19.90

DOI: 10.2108/zsj.18.905


Other references

Ciufo, R.; Nethery, D.; DiMarco, A.; Supinski, G., 1995: Effect of varying load magnitude on diaphragmatic glutathione metabolism during loaded breathing. Some studies have suggested that protective mechanisms downregulate diaphragm activity during loaded breathing so as to prevent respiratory-muscle fatigue. Other work has indicated, however, that loading can sometimes elicit significant diaphragma...

Zarinabad, N.; Chiribiri, A.; Hautvast, G.L.T.F.; Ishida, M.; Schuster, A.; Cvetkovic, Z.; Batchelor, P.G.; Nagel, E., 2013: Voxel-wise quantification of myocardial perfusion by cardiac magnetic resonance. Feasibility and methods comparison. The purpose of this study is to enable high spatial resolution voxel-wise quantitative analysis of myocardial perfusion in dynamic contrast-enhanced cardiovascular MR, in particular by finding the most favorable quantification algorithm in this co...

Senaratne M.P.J.; Hsu L.; Rossall R.E.; Kappagoda C.T., 1988: Exercise testing after myocardial infarction relative values of the low level predischarge and the postdischarge exercise test. This study was undertaken to compare the relative values of the low level predischarge exercise test and the postdischarge (6 weeks) symptom-limitied test in 518 consecutive patients admitted with an acute myocardial infarction. Of the patients wh...

Ripley, Edward M., 2011: Mechanisms for the attainment of sulfide saturation in magmas derived from subcontinental lithospheric mantle. Magmatic, sulfide-rich, Ni-Cu-(PGE) deposits occur in settings where potential interaction between mantle-derived magma and country is enhanced (and hence a particular significance to subcontinental lithospheric mantle). Although the presence of S...

Honda, S.; Hayashi, S.; Nakane, T.; Imoto, I.; Kurosawa, K.; Mizuno, S.; Okamoto, N.; Kato, M.; Yoshihashi, H.; Kubota, T.; Nakagawa, E.; Goto, Y-Ichi.; Inazawa, J., 2012: The incidence of hypoplasia of the corpus callosum in patients with dup (X)(q28) involving MECP2 is associated with the location of distal breakpoints. Duplications of Xq28 harboring the methyl CpG binding protein 2 (MECP2) gene explain approximately 1% of X-linked intellectual disability (XLID). The common clinical features observed in patients with dup(X)(q28) are severe ID, infantile hypotonia...

Merskey, C.; Lackner, H., 1959: The coagulability of blood in relation to coronary heart diseases. Postgraduate Medical Journal 35(402): 203-7 Passim

Lemmer, Börn., 2007: Importance of circadian rhythms for regulation of the cardiovascular system--studies in animal and man. In all mammals the cardiovascular system is highly organised in time. Pathophysiological cardiovascular events also do not occur at random (e.g. sudden cardiac death, stroke, ventricular arrhythmias, arterial embolism, symptoms of coronary heart d...

Reinoehl Kompa S., 1985: Population ecology of foraminifera in the northeastern Ems-Dollart Estuary, southern North Sea. Senckenbergiana Maritima 17(1-3): 147-161

Stoye, J.P.; Kaushik, N.; Jeremiah, S.; Best, S., 1995: Genetic map of the region surrounding the retrovirus restriction locus, Fv1, on mouse chromosome 4. The Friend virus susceptibility-1 (Fv1) gene maps to mouse Chromosome (Chr) 4 close to a cluster of four endogenous murine leukemia viruses (MLVs). To investigate the feasibility of cloning Fv1 by a positional approach, we have performed an extens...

Monaco, R.; Chen, J.M.; Chung, D.; Brandt-Rauf, P.; Pincus, M.R., 1995: Comparison of the computed three-dimensional structures of oncogenic forms (bound to GDP) of the ras-gene-encoded p21 protein with the structure of the normal (non-transforming) wild-type protein. The ras-oncogene-encoded p21 protein becomes oncogenic if amino acid substitutions occur at critical positions in the polypeptide chain. The most commonly found oncogenic forms contain Val in place of Gly 12 or Leu in place of Gin 61. To determine...