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A novel class A extended-spectrum beta-lactamase (BES-1) in Serratia marcescens isolated in Brazil


, : A novel class A extended-spectrum beta-lactamase (BES-1) in Serratia marcescens isolated in Brazil. Antimicrobial Agents and ChemoTherapy 44(11): 3061-3068

Serratia marcescens Rio-5, one of 18 extended-spectrum beta-lactamase (ESBL)-producing strains isolated in several hospitals in Rio de Janeiro (Brazil) in 1996 and 1997, exhibited a high level of resistance to aztreonam (MIC, 512 mug/ml) and a distinctly higher level of resistance to cefotaxime (MIC, 64 mug/ml) than to ceftazidime (MIC, 8 mug/ml). The strain produced a plasmid-encoded ESBL with a pI of 7.5 whose bla gene was not related to those of other plasmid-mediated Ambler class A ESBLs.

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PMID: 11036023


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