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A retrospective study of endometrial carcinoma in tamoxifen-treated breast cancer patients


, : A retrospective study of endometrial carcinoma in tamoxifen-treated breast cancer patients. Zhongguo Zhongliu Linchuang 25(9): 637-641, Sept

A retrospective study of risk and histologic features of endometrial carcinoma in patients with a history of breast cancer was done to investigate the effects of Tamoxifen (TAM). Twenty-five cases of endometrial carcinoma developed in TAM-treated breast cancer patients were identified by investigating case records. Thirteen of the 25 cases had prior TAM therapy, 12 had none. There were only 9 cases which accounted for 2.1% of the total endometerial carcinoma cases treated in the hospital during a 25 years period of time before 1990. 84.6% of the cases in the TAM group were of low grade (grade 1-2)endometrioid adenocarcinoma, similar to that in the, non-TAM group. Postmenopausal patients or those who had a family history of malignant tumors were readily more predisposed to develop endometrial carcinoma under the affect of TAM. TAM increased the risk of endometrial carcinoma. There were no significant differences of the histologic type and grade between TAM group and non-TAM group.

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D.G.aaf, G.; Van Hove, G.; Haveman, M., 2015: A quantitative assessment of educational integration of students with Down syndrome in the Netherlands. In the Netherlands, as in many other countries, there are indications of an inclusive school policy for children with Down syndrome. However, there is a lack of studies that evaluate to what extent this policy has actually succeeded in supporting...

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