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A retrospective study of endometrial carcinoma in tamoxifen-treated breast cancer patients

, : A retrospective study of endometrial carcinoma in tamoxifen-treated breast cancer patients. Zhongguo Zhongliu Linchuang 25(9): 637-641, Sept

A retrospective study of risk and histologic features of endometrial carcinoma in patients with a history of breast cancer was done to investigate the effects of Tamoxifen (TAM). Twenty-five cases of endometrial carcinoma developed in TAM-treated breast cancer patients were identified by investigating case records. Thirteen of the 25 cases had prior TAM therapy, 12 had none. There were only 9 cases which accounted for 2.1% of the total endometerial carcinoma cases treated in the hospital during a 25 years period of time before 1990. 84.6% of the cases in the TAM group were of low grade (grade 1-2)endometrioid adenocarcinoma, similar to that in the, non-TAM group. Postmenopausal patients or those who had a family history of malignant tumors were readily more predisposed to develop endometrial carcinoma under the affect of TAM. TAM increased the risk of endometrial carcinoma. There were no significant differences of the histologic type and grade between TAM group and non-TAM group.


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Wang, Y.; Sassoon, D., 1995: Ectoderm-mesenchyme and mesenchyme-mesenchyme interactions regulate Msx-1 expression and cellular differentiation in the murine limb bud. The apical ectodermal ridge (AER) is a specialized thickening of the distal limb mesenchyme that has been demonstrated to support limb outgrowth and proper limb development. The homeobox gene, Msx-1, is associated with the distal limb mesenchyme (...

D.G.aaf, G.; Van Hove, G.; Haveman, M., 2015: A quantitative assessment of educational integration of students with Down syndrome in the Netherlands. In the Netherlands, as in many other countries, there are indications of an inclusive school policy for children with Down syndrome. However, there is a lack of studies that evaluate to what extent this policy has actually succeeded in supporting...

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Rassnick, K.M.; Williams, L.E.; Kristal, O.; Al-Sarraf, Rée.; Baez, J.L.; Zwahlen, C.H.; Dank, G., 2008: Lomustine for treatment of mast cell tumors in cats: 38 cases (1999-2005). Objective-To determine clinical activity and toxic effects of lomustine when used to treat cats with mast cell tumors (MCTs).Design-Retrospective case series.Animals-38 cats with measurable, histologically or cytologically confirmed MCTs treated...

Chang, Y.; Zhang, G-Zhen.; Piao, S-Lan.; Gao, S.; Zheng, D-Ming.; Song, Y.; Tsicopoulos, A.; Ying, S., 2010: Protective effects of combined micronutrients on islet beta-cells of streptozotocin-induced diabetic mice. There is a tendency for the incidence of diabetes in a population to increase with an improvement in living standards. This would imply the involvement of nutritional factors in the development of diabetes, and so nutritional considerations could...

Berkovitz, A.; Eltes, F.; Soffer, Y.; Zabludovsky, N.; Beyth, Y.; Farhi, J.; Levran, D.; Bartoov, B., 1999: ART success and in vivo sperm cell selection depend on the ultramorphological status of spermatozoa. Management of male infertility has recently shifted from treatment of the subfertile man towards techniques of assisted reproduction (ART). This study aimed to evaluate the possible role of the ultramorphological status of the spermatozoon with re...