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A specific force deficit exists in skeletal muscle after partial denervation


, : A specific force deficit exists in skeletal muscle after partial denervation. Muscle & Nerve 25(1): 31-38, January

Skeletal muscle demonstrates a specific force deficit after repair of injured peripheral nerves, microneurovascular muscle transfer, and normal aging. Because atrophy cannot account for deficits in specific force, other, unknown, mechanisms are responsible for the resulting muscle contractile dysfunction under these circumstances. We tested the hypothesis that a subpopulation of denervated fibers is partially or completely responsible for the specific force deficit after partial denervation of the rat extensor digitorum longus muscle (EDL). Adult Fisher rats underwent either sham exposure or partial transection of 80% of the cross-sectional area of the left deep peroneal nerve. After a 2-week recovery period, maximum isometric force (Fo) was measured in situ and maximum specific force (sFo) was calculated for EDL from both control (n = 8) and partial denervation (n = 7) groups. Innervated fiber cross-sectional area (CSAinn) was measured directly from whole EDL cross sections after immunohistochemical labeling for neural cell adhesion molecule (NCAM), a marker of muscle fiber denervation. A corrected specific force value (sFo-inn) was calculated by normalizing Fo to CSAinn. Partial skeletal muscle denervation resulted in significant reductions in muscle mass, Fo, and sFo. The percentage of muscle fibers expressing NCAM in the extrajunctional sarcolemma increased from 1.0 +- 0.8% in control to 49 +- 15% in partially denervated EDL muscles. A 62.7% deficit in EDL specific force was observed after partial denervation. Denervated muscle fibers accounted for 59.3% of this deficit, but sFo-inn still differed significantly between control and partially denervated muscles, with a 25.5% difference between groups. In partially denervated muscles, the specific force deficit is partially but not fully explained by a subpopulation of noncontractile, denervated fibers.

US$19.90

DOI: 10.1002/mus.1216


Other references

Lin, V.K.; Agris, P.F., 1980: Alterations in tRNA isoaccepting species during erythroid differentiation of the Friend leukemia cell. The chromatographic profiles of isoaccepting tRNAs were analyzed at five time points during the 96 hr, dimethylsulfoxide induced, erythroid-like differentiation of Friend leukemia cells. Sixty-four isoaccepting species of tRNA for 16 amino acids w...

Shapiro, M.A., 2013: Using equivalent doses of medications to convert atrial fibrillation. American Journal of Cardiology 111(10): 1539-1539

Schneider H J.; Rugendorff E.W., 1984: Treatment of urinary stress incontinence by trans urethral submucosal injection of teflon. Journal of Urology 131(4 PART 2): 309A

Driessen, F.M.; Stadhouders, J., 1975: The lipolytic enzymes and co-factors responsible for spontaneous rancidity in cow's milk. Spontaneously rancid milk contains thermostable co-factors, probably phospholipoproteins, which form a complex with the lipoprotein lipase. The complex adsorbs to the fat globules and the fat is hydrolysed. In colostrum, a lipase has been detected...

Miketuková, V.; Kácl, K., 1965: The spectrophotometric microdetermination of thallium in biological material. Ceskoslovenska Farmacie 14(9): 470-474

Shooter E.M.; Miledi R.; Reese T.S.; Mutt V., 1989: Fidia research foundation neuroscience award lectures vol 3 1987 1988. Volume 3 of this series contains lectures of the 4 scientists who have been awarded by the Fidia Research Foundation for the year 1987-1988. The lectures review pertinent information regarding the advancement of neuroscience and address the topics...

Chandonia, J-Marc.; Brenner, S.E., 2006: The impact of structural genomics: expectations and outcomes. Structural genomics (SG) projects aim to expand our structural knowledge of biological macromolecules while lowering the average costs of structure determination. We quantitatively analyzed the novelty, cost, and impact of structures solved by SG...

Kiris, I.D., 1958: New data on winter diet of Yenisei sables. Translation of the Russian Game Reports (Canadian Wildlife Service): 5: 18-27

Viveiros, M.; Rodrigues, L.; Martins, M.; Couto, I.; Spengler, G.; Martins, A.; Amaral, L., 2010: Evaluation of efflux activity of bacteria by a semi-automated fluorometric system. A semi-automated method that uses the common efflux pump (EP) substrate ethidium bromide (EB) is described for the assessment of EP systems of bacteria. The method employs the Rotor-Gene(TM) 3000 thermocycler (Corbett Research) for the real-time a...

Anonymous, 2007: Proceedings of the 2006 World Transplant Congress, Boston, Massachusetts, USA. Transplantation 82(12): 1557-1791