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A study on the relationship between genetic and environmental factors of type 2 diabetes mellitus in humans

, : A study on the relationship between genetic and environmental factors of type 2 diabetes mellitus in humans. Zhonghua Yu Fang Yi Xue Za Zhi 36(3): 191-194

Objective: To study the relationship between the inheritable factor and environmental factors of type 2 diabetes mellitus in humans. Methods: A case-control study based on 154 type 2 diabetes mellitus and 130 healthy controls was carried out in Jiangsu Province in 1997. Results: The age, family history of diabetes mellitus, hypertension history, high waist/hip ratio (WHR), high systolic blood pressure, huge fetus history, and the genotype of beta3-adrenergic receptor (beta3-AR) were the risk factors of type 2 diabetes mellitus; while occupational physical activity was protective factor of type 2 diabetes mellitus. The risk for diabetes mellitus distinctly increased while genetic factor and obesity, beta3-AR mutation were coexisting. Conclusion: Type 2 diabetes mellitus is caused by the effect of both genetic and environmental factors.


PMID: 12410955

Other references

Antoine, J.C., 2002: Paraneoplastic peripheral neuropathies. Revue Neurologique 157(12): 1557-1560

Hulsemann, K.; Fleminger, A., 1975: Some aspects of copepodid development in the genus Pontellina Dana (Copepoda: Calanoida). Bulletin Mar Sci, 252: 174-185

Povoa, H.; Souza, A.C.; Teixeira, L.C.; Sargentelli, L., 1973: Plasmalogens in ischaemic heart disease. Acta Biologica et Medica Germanica 31(6): 897-898

Orr W.C.; Allen M.; Finn A.; Robinson M.G., 1988: Timing of evening meal and ranitidine administration on patterns of 24 hr intragastric ph. Annual Review of Chronopharmacology : 321-322

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