geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Acute mountain sickness, dehydration, and bicarbonate clearance: preliminary field data from the Nepal Himalaya


, : Acute mountain sickness, dehydration, and bicarbonate clearance: preliminary field data from the Nepal Himalaya. Aviation, Space, and Environmental Medicine 73(9): 898-901

Background: In 1999, Basnyat et al. published preliminary data demonstrating an inverse correlation between hydration status and acute mountain sickness during an epidemiological study performed in the vicinity of Mount Everest. To expand on these findings, we have returned to the Langtang area of the Nepal Himalaya to perform more specific studies of altitude illness related to dehydration and hypoxemia using urine studies, pulse oximetry, and physical examination. Hypothesis: Dehydration will incite physiological changes aimed at the preservation of vascular volume homeostasis characterized by the production of sodium and water sparing hormones. As sodium is reabsorbed in the kidney, bicarbonate anion is also reabsorbed resulting in insufficient bicarbonate anion excretion by the kidney leading to an incomplete compensation for altitude induced hypocapnic alkalosis and the development of clinical disease. Methods: Estimates of intravascular volume (urine specific gravity), oxygen saturation (pulse oximetry), urinary bicarbonate excretion (urine pH), and AMS (Lake Louise Score) were collected from Hindu pilgrims at 4243 m during an annual sacred festival at Lake Gosinkunda. Results: Worsening altitude illness approximated by increasing Lake Louise Score was associated with increasing urine specific gravity (p=0.043), decreasing oxygen saturation (p=0.020), and decreasing urine pH (p=0.040) after rapid ascent to 4243 m. Conclusions: Worsening altitude illness, indicated by increasing Lake Louise score, was associated with increasing measures of dehydration, hypoxemia, and urine acidity.

US$29.90

PMID: 12234041


Other references

Stohler, R., 1959: Why Rules of priority?. Veliger Berkeley Calif, 2: 17-18

Smith, J.; Al-Amri, M.; Sniderman, A.; Cianflone, K., 2006: Leptin and adiponectin in relation to body fat percentage, waist to hip ratio and the apoB/apoA1 ratio in Asian Indian and Caucasian men and women. Asian Indian immigrants have an increased risk for developing cardiovascular disease (CVD); however, there is very little data examining how the adipokines leptin and adiponectin relate to CVD risk factors such as body fat percentage (BF%), waist...

Letowski, Jacek., 1994: The weevils Coleoptera, Curculionidae of the Forest Reservation Las Klasztorny near Lezajsk The Sandomierz Lowland Ryjkowce Coleoptera, Curculionidae rezerwatu lesnego Las Klasztorny pod Lezajskiem Nizina Sandomierska. Annales Universitatis Mariae Curie-Sklodowska Sectio C Biologia. 1991( ); 46: 185-203

Amy J J., 1975: Induction of labor with prostaglandins. Karim, S (ed.). Advances In Prostaglandin Research. Prostaglandins And Reproduction. X 332p. Illus. University Park Press: Baltimore, Md., U.s.a. Isbn 0-8391-0839-9. 149-228

Vomund, S.; Sapir, T.; Reiner, O.; Silva, M.A.de.Souza.; Korth, C., 2014: Generation of topically transgenic rats by in utero electroporation and in vivo bioluminescence screening. In utero electroporation (IUE) is a technique which allows genetic modification of cells in the brain for investigating neuronal development. So far, the use of IUE for investigating behavior or neuropathology in the adult brain has been limited b...

Yang, N.; Wang, X.; Jiang, J.; Frank, S.J., 2007: Role of the growth hormone (GH) receptor transmembrane domain in receptor predimerization and GH-induced activation. The GH receptor (GHR) mediates GH effects by activating the GHR-associated cytoplasmic tyrosine kinase, Janus kinase 2. Recent studies indicate that GHRs exist as dimers independently of GH binding. Some authors suggest that receptor predimerizat...

Preuksaraj, S., 1984: Public health aspects of opisthorchiasis in Thailand. It is estimated that 7 million people in Thailand are infected with Opisthorchis viverrini. Of 43 339 villagers from 28 provinces in the 4 regions of Thailand examined in 1980/81, 23 686 (54.65%) were infected with parasites, and 14.72% with O. vi...

Bons, N.; Mestre, N.; Petter, A., 1992: Senile plaques and neurofibrillary changes in the brain of an aged lemurian primate, Microcebus murinus. In some aged Microcebus brains (8- to 11-year-old animals) dramatic atrophy is found, particularly of the cortex, the hippocampus, the basal ganglia, the brainstem and the cerebellum, associated with a conspicuous increase in the size of the cereb...

Carswell D.A.; Cuthbert S.J.; Krogh Ravna E.J., 1999: Ultrahigh-pressure metamorphism in the Western Gneiss Region of the Norwegian Caledonides. The distribution and characterization of UHP rocks within the Western Gneiss Region (WGR) of the Norwegian Caledonides is reviewed. While recent studies have documented a significantly increased number of eclogite localities preserving mineralogic...

Clarke, R.; Hilakivi-Clarke, L.; Cho, E.; James, M.R.; Leonessa, F., 1996: Estrogens, phytoestrogens, and breast cancer. Advances in Experimental Medicine and Biology 401: 63-85