geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Airway responsiveness to acetylcholine or capsaicin in immature and mature guinea pigs in vivo


, : Airway responsiveness to acetylcholine or capsaicin in immature and mature guinea pigs in vivo. Allergology International 49(2): 99-104, June

Non-specific airway hyperresponsiveness is a characteristic feature of bronchial asthma. Airway reactivity to cholinergics may change with age during childhood. The present paper describes tests to see if the airway responsiveness induced by acetylcholine (ACh) or capsaicin, which causes a release of endogenous tachykinins from the sensory nerve, changes with age in guinea pigs. Changes in lung resistance (RL) were measured to monitor airflow obstruction caused by intravenous ACh or capsaicin in anesthetized immature guinea pigs (aged 2 weeks), and to compare with those of adult guinea pigs (aged 11 weeks). It was shown that both ACh and capsaicin induced a rapid and dose-dependent increase in RL both in immature and adult animals. The two age groups had similar responsiveness to ACh or capsaicin in terms of potency or sensitivity. The response induced by capsaicin was not affected by atropine. In addition, capsaicin caused no extravasation of Evans Blue dye as an index of airway plasma exudation in both age groups. The airflow obstruction induced by i.v. capsaicin is mainly due to a cholinergic-unrelated smooth muscle contraction. These results suggest that airway smooth muscle responsiveness to cholinergics or capsaicin is comparable in both immature and adult guinea pigs in vivo.

US$19.90

DOI: 10.1046/j.1440-1592.2000.00166.x


Other references

D.S.lveira, A.C.; Oliveira, N.; Gonzalez, S.; Shahani, M.; Reisberg, D.; Daw Jr, J.L.; Cohen, M., 2003: Modified nasal alveolar molding appliance for management of cleft lip defect. Nasal alveolar molding is used effectively to reshape the nasal cartilage and mold the maxillary arch before cleft lip repair and primary rhinoplasty. It provides aesthetic and functional benefits of nasal tip and alar symmetry and improved dental...

Karpe, R.; Karpe, M.; Freud, S., 1979: The significance of Freud's trip to Orvieto. Israel Annals of Psychiatry and Related Disciplines 17(1): 3-20

Gaudy-Marqueste, C., 2008: Other immunosuppressants: azathioprine (Imurel), mycophenolate mofetil (Cellcept), cyclophosphamide (Endoxan). Annales de Dermatologie et de Venereologie 134(12): 949-956

Liu, Y.; Dong, J.; Liu, G.; Yang, H.; Liu, W.; Wang, L.; Kong, C.; Zheng, D.; Yang, J.; Deng, L.; Wang, S., 2016: Co-digestion of tobacco waste with different agricultural biomass feedstocks and the inhibition of tobacco viruses by anaerobic digestion. Tobacco is widely planted across the world especially in China, which means that a large amount of tobacco waste needs to be treated. This study investigated the biogas fermentation of tobacco stalks co-digested with different biomass feedstocks a...

Taylor, H.A.; Cloutier, P.A., 1988: Response: evidence of lightning and volcanic activity on venus: pro and con. Science 240(4849): 224-226

Robin, G.C., 1993: Orthopaedics in Israel. Bulletin ) 53(1): 7-8

Chernyĭ, V.V., 1978: Classification of paranasal sinusitis. Zhurnal Ushnykh, Nosovykh i Gorlovykh Boleznei 2): 60-62

Kardell L.; Persson O.; Carlsson E.; Eriksson L., 1980: Yield of mushrooms from swedish forest land. Collecting mushrooms has become a popular form of autumn recreation in Sweden. Modern forestry methods may reduce the mushroom yield from forest land in the future. An attempt to estimate the mushroom production of Swedish forests is reported. The...

Berdar, A.; Capecchi, D.; Costa, F.; Giordano, D.; Mento, G.; Spalletta, B., 1995: Parasitized and pseudoparasitized fish of the Italian Seas Pesci parassiti e pseudoparassiti dei mari italiani. Rivista di Parassitologia. Dicembre; 123: 453-465

Zemlyanukhin A.A.; Zvyagintsev V.I., 1969: Changes in the glycolytic activity of yeasts due to the action of hetero auxin. Nauchnye Doklady Vysshei Shkoly Biologicheskie Nauki 12(5): 93-96