+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Alterations in contractile properties and expression of myofibrillar proteins in wobbler mouse muscles

, : Alterations in contractile properties and expression of myofibrillar proteins in wobbler mouse muscles. Experimental Neurology 162(2): 311-320

The purpose of this study was to characterize the alterations in muscle contractile (tension-pCa relationship) and biochemical (myosin heavy and light chains, troponin C content) properties in a hereditary motoneuron disease. The study was performed on wobbler mouse mutants which presented a neuronal degeneration. The time course of the disease was followed at 5 and 7 weeks in sternocleidomastoid (SCM) and soleus muscles. The wobbler disease was found to induce a shift from fast to slow myosin heavy-chain isoform expression in SCM and soleus muscles. The analysis of the myosin light-chain (MLC) composition revealed, for the SCM muscles, the appearance of the slow isoforms at 5 weeks and an increase in the regulatory MLC2 content at 7 weeks. A significant increase in the slow troponin C isoform content was found in both types of wobbler muscles at 7 weeks. The wobbler soleus and SCM muscles presented an age- and fiber-type-related atrophy, characterized by a decline in absolute maximal tension and fiber diameter. A decrease in calcium sensitivity was observed at 7 weeks for the soleus fibers and at both 5 and 7 weeks for the SCM. The results indicated fast-to-slow changes in contractile and biochemical properties of the wobbler soleus and SCM muscles, which occurred during the motoneuron degeneration process previously described in the wobbler pathology.


PMID: 10739637

DOI: 10.1006/exnr.1999.7349

Other references

Belilovskaia, A.I.skina, N., 1980: Activities of the subcommittee on Cereals and Legumes of the International Organization on Standardization. Mukomol'no elevatornaia i kombikormovaia promyshlennost': (11) 44-45

Reid, G.; Yip, S., 2014: Welcome message from conference co-convenors. Asia-Pacific Journal of Clinical Oncology 10 Suppl 7: 1-1

Jourdi, H.; Lin, B.; Yanagihara, T.; Bi, X.; Baudry, M.; Lynch, G., 2003: Using RNA interference to modify the subunit composition of synaptic AMPA receptors. Considerable attention has been given to the question of how subunit composition affects the biophysics and modulator pharmacology of AMPA-type glutamate receptors. While much has been learned from studies using transfected cells expressing homome...

Hansen, E.F.; Rasmussen, F.V.; Hardt, F.; Kamstrup, O., 1999: Lung function and respiratory health of long-term fiber-exposed stonewool factory workers. The present study was undertaken to examine the respiratory health of a Danish workforce exposed to man-made vitreous fibers (MMVF) during production. Workers with more than 5 yr occupational exposure to MMVF (n = 377) were compared to a group wit...

Shimizu, W.; Ohe, T.; Antzelevitch, C., 2000: Early afterdepolarizations and polymorphic ventricular arrhythmias in acquired and congenital long QT syndrome Observations from clinical and experimental studies. Franz, Michael R Monophasic action potentials: Bridging cell and bedside 641-658

Hrudka, F.; Rakicky, P., 1966: Changes in activity of endogenous reductases, succinate dehydrogenase and the motility of bovine spermatozoa under the influence of high temperatures. Folia Morphologica 14(3): 221-231

Sanchez, J.; Ettiene, G.; Buscema, I.; Medina, D., 2005: Persistence of organophosphorus malathion and chlorpiryphos insecticides in guava (Psidium guajava L.). A laboratory study was conducted to determine the malathion and chlorpiryphos [chlorpyrifos] persistence in physiologically mature guavas. The commercial formulations were applied at 2 litre malathion and 1.5 litre chlorpiryphos/ha. The residual l...

Wolfinbarger, Lloyd, 2000: Process and composition for cleaning soft tissue grafts optionally attached to bone and soft tissue and bone grafts produced thereby. The invention relates to compositions effective for the cleansing of mammalian soft tissue optionally attached to bones, and particularly the removal of blood deposits and bone marrow therefrom. The compsotions are composed of an aqueous solution...

Reiner, Željko.; Tedeschi-Reiner, E., 2013: Prevalence and types of persistent dyslipidemia in patients treated with statins. To determine the prevalence and types of persistent dyslipidemia in patients treated with different statins to reduce cardiovascular disease (CVD) risk, as well as to determine the proportion of high risk patients who did not reach the lipid targe...

Doehn, C.; Böse, N.; Meyer, A.; Jocham, D., 2010: Whose transplant function fails after ureteral revision following kidney transplantation?. Kidney transplantation is associated with ureteral complications in about 5% of cases. While many reasons for ureteral complications are known, it is currently unknown whether transplant outcomes are affected by operative revision of the transplan...