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Amino acid-derived heterocycles as combinatorial library targets: spirocyclic ketal lactones

, : Amino acid-derived heterocycles as combinatorial library targets: spirocyclic ketal lactones. Journal of Combinatorial Chemistry 5(3): 285-291

The spirocyclic ketal-lactone frameworks of 3 and 4 were designed as novel structures amenable to combinatorial synthesis. The synthesis of representative analogues was developed in solution and on solid support, the scope of effective input materials was determined, and the stability and stereochemistry of the products was evaluated. The spirocycles are obtained in modest overall yields (5-36%) and excellent purities (>72%) and offer a promising motif for combinatorial prospecting libraries.


PMID: 12739946

DOI: 10.1021/cc020081q

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