+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

An hypothesis concerning control networks and aging in Drosophila melanogaster and Caenorhabditis elegans

, : An hypothesis concerning control networks and aging in Drosophila melanogaster and Caenorhabditis elegans. Journal of the American Aging Association 24(4): 173-177

To explain trends emerging from the study of longevity mutants, a modification of the reactive oxygen species (ROS) model of aging is suggested. ROS do not appear to be produced in greater quantities during cellular activity unless specific factors are also present. These include raised cytosolic calcium and sodium ions, nitric oxide (NO) or dopamine. Metabolically active cells that are repeatedly exposed to these factors, especially in combination, show the most ROS damage and may contribute most to aging. This explains the importance of neurons, which is highlighted by genetic studies, and points to which cells are the most aging-sensitive. Control pathways disrupted in long-lived mutants are those which control one or more of these ROS promoting factors. The daf-2/daf-16 pathway may interact with these factors in several ways. Changes in control networks may be propagated from a relatively small number of cells/junctions by neural connectivity and hormonal means.


PMID: 23604882

DOI: 10.1007/s11357-001-0018-0

Other references

Friederich, H-Christoph.; Brooks, S.; Uher, R.; Campbell, I.C.; Giampietro, V.; Brammer, M.; Williams, S.C.R.; Herzog, W.; Treasure, J., 2010: Neural correlates of body dissatisfaction in anorexia nervosa. Body dissatisfaction is an important precipitating and maintenance factor in anorexia nervosa (AN) and behavioral studies suggest that a cognitive-affective component and a perceptual component (perceptual disturbance of one's own body) are b...

Lelievre J.; Mirza I.A.; Tung M.A., 1992: Failure testing of gellan gels. Gels, formed using a 1% gellan gum solution containing 7 mM calcium ions, were tested to failure in compressive, tensile and torsional modes. The gels were brittle and fractured at relatively small strains. In the compression experiments samples f...

Leclercq, J., 1951: Foxita patei nov. sp., Crabronien nouveau du Mexique (Hym. Sphecid.). Mitteilungen der Schweizerischen Entomologischen Gesellschaft, 24: 190

D.L.F.ente M.; Alia M.; Fraile A., 1981: Effect of semi carbazide on the pulmonary levels of nucleic acid and proteins in the rat. Semicarbazide, administered i.p. (100 mg/kg) reduces the nucleic acids and pulmonary protein levels of adult, pregnant, newborn or fetal rats. The pregnant rats were administered semicarbazide on the 10th day of their pregnancy. The reduction of t...

Verhoestraete, L.J.; Puffer, R.R., 1957: Data on maternal and child mortality as a basis for program planning. Courrier 7(4): 185-192

Starkey, J.A.; Mechref, Y.; Byun, C.K.; Steinmetz, R.; Fuqua, J.S.; Pescovitz, O.H.; Novotny, M.V., 2002: Determination of trace isoflavone phytoestrogens in biological materials by capillary electrochromatography. Capillary electrochromatography using a specialty monolithic matrix was utilized in developing a rapid and highly efficient separation of isoflavones in biological materials. Without a preconcentration technique, it is relatively easy to reach ppm...

Lederman, D., 1993: Oral medicine: it's basic dentistry. New York State Dental Journal 59(3): 35-37

Pospichalova, K.; Vodicka, J.; Kopal, A., 2016: New test of odor pleasantness in Parkinson's disease. NlmCategory="UNASSIGNED">The New Test of Odor Pleasantness (NTOP) evaluates the hedonicity of olfactory stimulants. The aim of this study was to compare results of the NTOP, the Sniffin' Sticks test, and the Odorized Marker Test...

Evenchick Carol A.; McNicoll Vicki J., 2002: Stratigraphy, structure, and geochronology of the Anyox Pendant, Northwest British Columbia, and implications for mineral exploration. Anyox Pendant contains complexly deformed greenschist-facies volcanic strata overlain by a thick succession of turbidite sedimentary rocks. At the contact between the two are well-studied copper-rich volcanogenic massive sulphide deposits; however...

Suntych, F., 1962: Brucellosis as an occupational disease.. In a district where brucellosis in domestic livestock was considered to have been eradicated, 43 of 765 people developed the disease, probably from contact with either farm manure or wild life. Later there were new outbreaks affecting four piggeri...