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Arylsulfonyl-N,N-diethyl-dithiocarbamates: A novel class of antitumor agents

, : Arylsulfonyl-N,N-diethyl-dithiocarbamates: A novel class of antitumor agents. Bioorganic & Medicinal Chemistry Letters 10(16): 1887-1891, 21 August

A series of alkyl/arylsulfonyl-N,N-diethyl-dithiocarbamates has been prepared by reaction of sodium N,N-diethyldithiocarbamate with alkyl/arylsulfonyl halides. The reactivity of these new derivatives against cysteine and glutathione has been investigated in order to identify derivatives that might label a critical cysteine residue of tubulin (Cys 239 of human beta2 tubulin chain). Some of the most reactive compounds showed moderate to powerful tumor growth inhibitory properties against several leukemia, non-small cell lung, ovarian, melanoma, colon, CNS, renal, prostate and breast cancer cell lines in vitro.


PMID: 10969992

DOI: 10.1016/s0960-894x(00)00375-9

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