geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Basic fibroblast growth factor increases tissue factor expression in circulating monocytes and in vascular wall


, : Basic fibroblast growth factor increases tissue factor expression in circulating monocytes and in vascular wall. Circulation 101(16): 2000-2006

Background-Basic fibroblast growth factor (bFGF) promotes vascular repair and angiogenesis and can induce in vitro tissue factor (TF), a potent agent initiating thrombogenesis, which probably plays a role in angiogenesis. We investigated whether bFGF administration induced TF expression by monocytes and vascular cells. Methods and Results-We studied TF expression in normally fed (n=16) and cholesterol-fed (2% for 6 weeks, n=16) rabbits. Animals were then randomized to receive intravenous bFGF (2.5 mug twice weekly for 3 weeks) or saline injections. TF expression was evaluated in mononuclear cells from arterial blood and in aortic sections by an immunohistochemical assay using a monoclonal anti-rabbit TF antibody (activator protein 1). Monocyte TF expression was increased by bFGF administration in both normal and hypercholesterolemic rabbits (129+-45 versus 19+-3 mU TF/1000 monocytes, P<0.05, and 31+-12 versus 7+-1 mU TF/1000 monocytes, P<0.005, respectively) and was further increased by stimulation of monocytes by endotoxin in vitro. TF expression was lower in hypercholesterolemic rabbits than in normal rabbits. In the media of the vascular wall, bFGF induced strong TF expression in normal rabbits and only weak TF expression in hypercholesterolemic ones. Conclusions-This study demonstrates that systemic administration of bFGF induces an impressive increase of TF expression in circulating monocytes and in the vascular wall in normal and to a lower extent in hypercholesterolemic rabbits. The significance of this observation in terms of inducing thrombosis in vivo needs clarification.

US$19.90

PMID: 10779468

DOI: 10.1161/01.CIR.101.16.2000


Other references

Watanabe, T.; Kitamura, D.; Taniuchi, I.; Fukuda, T.; Maekawa, Y., 1994: HS1 as a novel signal transmitter from B cell antigen receptor. Journal of Cellular Biochemistry Supplement 0(18D): 349

Distler, O.; Pope, J.; Denton, C.; Allanore, Y.; Matucci-Cerinic, M.; de Oliveira Pena, J.; Khanna, D., 2016: RISE-SSc: Riociguat in diffuse cutaneous systemic sclerosis. NlmCategory="UNASSIGNED">RISE-SSc is a randomized, double-blind, placebo-controlled phase 2 study investigating the efficacy and safety of riociguat in patients with diffuse cutaneous systemic sclerosis (dcSSc). Based on positive resu...

Prohaska, F., 1940: Erfahrungen mit einem Doppel-thermometer zur Messung der kalorischen Einstrahlung. A modification of the Arago-Davy double thermometer enclosing both the half-spherical black and blank bulb thermometers in one partly evacuated glass sheath is presented. The instrument has an accommodation time of 10 to 15 min. The calibration fa...

Dickore, W.B., 1991: Zonation of flora and vegetation of the northern declivity of the Karakoram/Kunlun mountains (SW Xinjiang China). The N. declivity from K2 (8611 m) to the edge of the Tarim basin was explored in Aug.-Nov. 1986. A vegetation transect from 1300 m to 5200 m alt. is described. The colline belt from 1300 to 2100 m was characterized by Zygophyllum xanthoxylon, the...

Maruyama, T.; Yamamoto, H., 2004: Evaluation of image quality in mammographic film with the extended process. This report deals with the image quality of film used in mammography in terms of changing the processing time of the film and reducing the radiation dose. We initially performed phantom experiments to investigate the extended process that could pr...

Minato, Y.; Nihei, Y.; Kodama, Y.; Tashiro, E.; Kanai, M.; Imoto, M., 2008: Identification and characterization of mouse type II platelet-derived growth factor receptor alpha transcript. Recently, we identified a novel human platelet-derived growth factor (PDGF) receptor alpha mRNA (type II) that differs from the known human PDGF receptor alpha mRNA (type I) only in its 5'-untranslated region and is regulated by E2F-1. In thi...

Brice, J.; Kourie, C., 2006: Contemplation and compassion: the heart of a Franciscan spirituality of clinical pastoral supervision. After five years of supervising CPE modules in two different hospitals in South Africa, a chaplain supervisor reflects on how his Franciscan spirituality had impacted his supervisory ministry. He describes how he was able to narrow the impact to t...

Wernecke K D.; Baumler H.; Kalb G., 1983: The applicability of multi dimensional classification procedures. Examples from patients' EEG-analysis shows that in using the R-error estimation, variance analysis and discrimination might indicate contradictory results. Therefore the use of MANOVA [multivariate analysis of variance] for a subsequent discr...

Lee, Y.M.; Kim, S.S.; Kim, S.H., 2004: Synthesis and properties of poly(ethylene glycol) macromer/beta-chitosan hydrogels. Semi-interpenetrating polymer network (semi-IPN) hydrogels composed of beta-chitosan and poly(ethylene glycol) diacrylate macromer (PEGM) were synthesized and characterized for the application as potential biomedical materials. The mixture of PEGM...

Nonnenmacher J.; Neumeier K., 1987: Intrafocal pinning in radius fractures. This method discussed by Kapandji (1976) in which pins are passed through the fracture line and not through the styloid process provides dynamic pinning in comminuted fractures in the adult resulting from compression and extension. No plaster is u...