geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

COX-2 inhibitors prolong trauma-induced elevations of iris hyaluronan


, : COX-2 inhibitors prolong trauma-induced elevations of iris hyaluronan. Journal of Ocular Pharmacology and Therapeutics 19(4): 385-395

Purpose: To investigate whether and how treatment with COX-2 inhibitors influences hyaluronan responses to a standardized trauma, argon laser induced iritis, in rabbits. Methods: Two different COX-2 inhibitors were used, SC-236 and rofecoxib. The drugs were administered orally, 6 mg/kg/day and 1.5 mg/kg/day respectively. Iris and aqueous humor hyaluronan concentrations were measured with a radiometric assay at different time points after laser irradiation. Results: The hyaluronan concentration in the iris increased 3-4-fold with a peak concentration of 129.1 mug/g wet weight 2 days after laser irradiation. It then decreased to normal values after 1 week. In eyes treated with either of the COX-2 inhibitors, iris hyaluronan concentrations did not decrease as rapidly and were significantly higher at day 4 and 7 when compared to drug untreated eyes. Conclusion: Treatment with COX-2 inhibitors prolongs trauma induced elevation of iris content of endogenous hyaluronan. This may be, at least partly, due to an inhibition of interstitial fluid pressure regulation.

US$19.90

PMID: 12964963

DOI: 10.1089/108076803322279444


Other references

Weiss, N.S.; Hamill, P.V.; Drizd, T., 1973: Blood Pressure levels of Children 6-11 Years: Relationship to Age, Sex, Race, and Socioeconomic Status, United States. This report presents the distribution of blood pressure levels of U.S. children aged 6-11 years by age, sex, and race. Data were obtained in Cycle II of the Health Examination Survey (HES), which is one of the major programs of the National Center...

Nyholm K.; Reed G.; Sjolin K E., 1967: Neopl letterer siwe disease human neopl reticulo endotheliosis. Acta Pathologica et Microbiologica Scandinavica 70(4): 481-500

Weinberg, G.A., 2005: Question from the clinician: hepatitis B vaccine birth dose. Pediatrics in Review 26(6): 226-227

Ramon, C.; Gehin, C.; Schmitt, P.M.; Dittmar, A., 2007: Interface pressure monitoring for a secured instrumented childbirth. Complications in forceps deliveries are rare but their consequences might be dramatics. This situation could be avoided if the obstetrician knows the information concerning symmetry of the obstetrical forceps position on the fetal head and the rel...

Takaza, M.; Moerman, K.M.; Simms, C.K., 2014: Passive skeletal muscle response to impact loading: experimental testing and inverse modelling. Appropriate mechanical representation of passive muscle tissue is crucial for human body impact modelling. In this paper the experimental and modelling results of compressive loading of freshly slaughtered porcine muscle samples using a drop-tower...

Alm, P.; Ekstrom, J.; Larsson, B.; Tobin, G.; Andersson, K.E.ik, 1997: Nitric oxide synthase immunoreactive nerves in rat and ferret salivary glands, and effects of denervation. Nitric oxide has been implicated in mechanisms mediating nerve-evoked vasodilatory and secretory responses in salivary glands. In the present study, the occurrence and distribution of nitric oxide synthase (NOS)-immunoreactive nerves in ferret and...

Bitar, M.; Baz, R.; Fuleihan, N.; Muallem, M., 2007: Can zinc be an adjuvant therapy for juvenile onset recurrent respiratory papillomatosis?. To report a severe case of juvenile onset recurrent respiratory papillomatosis (JORRP) controlled by zinc replacement therapy. To review the contemporary adjuvant therapies used in JORRP. The trial of zinc was described in terms of its effect on t...

Chen, X.; Li, S., 2014: Effects of enhanced atmospheric ammonia on physiological characteristics of maize(Zea mays L.). Elevated atmospheric NH₃ may affect photosynthesis rates and biomass production of crops and the effect may be responsible for the soil nitrogen (N) levels. Plants were exposed to 0 and 1000 nL L⁻¹ with and without N (+N and - N) in o...

Va.I.Erson.W.; Robinow.C.F., 1961: Observations with the electron microscope on the fine structure of the nuclei of two spherical bacteria. The nuclei of two spherical bacteria have been examined in electron micrographs of thin sections of specimens prepared by the method of Ryter and Kellenberger (1958). The nuclei appear to consist of the same fine fibers in a matrix of low density...

N.B.lheine; J.-P.P.assiard; F.-V.D.nzé; F.D.rve; A.S.ridi, 2009: Numerical simulation of drained triaxial test using 3D discrete element modeling. Computers and Geotechnics 36(1-2): 320-331