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CS1, a novel member of the CD2 family, is homophilic and regulates NK cell function

, : CS1, a novel member of the CD2 family, is homophilic and regulates NK cell function. Molecular Immunology 39(1-2): 1-8, September

CS1 is a novel member of the CD2 subset of immunoglobulin superfamily (IgSF) expressed on NK, T and stimulated B cells. The cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motif (ITSM) which is present in 2B4, SLAM and CD84. The signaling adaptor molecule SAP/SH2D1A, the defective gene in X-linked lymphoproliferative disease (XLPD), binds to ITSM and regulates immune cell function. However, recent studies indicate that CS1 may be regulated by a SAP-independent mechanism. In this study, we have examined the ligand specificity of CS1 and the effect of CS1 interaction with its ligand on the cytolytic activity of YT, a human NK cell line. Recombinant fusion protein, CS1-Ig, containing the CS1 extracellular domain and Fc portion of the human IgG bound cells transfected with CS1. CS1-Ig did not show any binding to cells expressing other members of the CD2 family. The cytolytic activity of YT was enhanced in presence of soluble CS1-Ig fusion protein. These results demonstrate that CS1 is a self-ligand and homophilic interaction of CS1 regulates NK cell cytolytic activity.


PMID: 12213321

DOI: 10.1016/s0161-5890(02)00094-9

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Abraham, Levente, 2003: A Latranyi Puszta Termeszetvedelmi Terulet recesszarnyu-alkatu (Megaloptera, Raphidioptera, Neuroptera) faunaja. In 1999 and 2001, the author carried out faunistical samplings in 6 different habitats of the protected area. Samplings were collected by light, portable light traps at night and by netting technique during the day. Altogether 434 specimens belong...

Matsukawa, N.; Matsumoto, M.; Hara, H., 2009: High biliary excretion levels of quercetin metabolites after administration of a quercetin glycoside in conscious bile duct cannulated rats. Biliary excretion of quercetin metabolites in conscious rats was biphasic, a high peak within 3 h and a lower peak for next 6 h, after duodenal administration of soluble quercetin glycosides. We also found much higher biliary excretion of querceti...

Sharma, M.K.; Joolka, N.K., 2003: Bioregulators mediated biochemical changes in Nonpareil almond under soil water stress. A study was conducted in Himachal Pradesh, India, to find the suitability of triacontanol and paclobutrazol in improving the drought tolerance of Nonpareil almond plants. One-year-old Nonpareil almond plants, sprayed with 5 and 10 ppm triacontanol...

Zhou, R.; Yang, Y.; Zhang, W.; Zou, Y., 2017: A Strain Feedback Compensation Method during Cell Tensile Experiments. Cell tensile technique is an important and widely used tool in cell mechanical research. However, the strain control condition in traditional tensile experiments is not satisfied and would result in big errors. These strain errors will seriously i...

Balicka, U., 1974: Immunoglobulins IgA, IgG and IgM levels in the serum and mixed saliva in superficial parodontopathy. Czasopismo Stomatologiczne 27(1): 87-96

Tisdall J.M.; Hodgson A.S., 1990: Ridge tillage in australia a review. This paper reviews research on ridge tillage in Australia. Ridge tillage is used successfully in Australia, mainly for vegetables or irrigated crops grown on poorly drained alfisols and vertisols. The better yields from crops grown on ridges compa...

Anonymous, 1970: Luna deserta. British Medical Journal 1(5698): 708-708

Busygin, V.P.; Mitrofanova, G.G.; Pavlova, K.V., 1982: Present status and outlook for the development of medical instruments with fiberoptic waveguides. Meditsinskaia Tekhnika: 47-53

Roe D.A.; Menges J., 1973: Distribution of sulfur 35 sulfate in fetal rats from dams fed salicylamide. Federation Proceedings 32(3 PART 1): 746

Dorn, L.A.; Schmitt, J., 1997: The genetics basis of phenotypic plasticity Do plasticity genes exist or not?. American Journal of Botany 84(6 SUPPL ): 68-69