geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Candidacidal activity of shortened synthetic analogs of amoebapores and NK-lysin


, : Candidacidal activity of shortened synthetic analogs of amoebapores and NK-lysin. Medical Microbiology & Immunology 188(3): 117-124, Dec

Natural antimicrobial peptides and synthetic analogs thereof have emerged as compounds with potentially significant therapeutical application against human pathogens. Amoebapores are 77-residue peptides with cytolytic and antibacterial activity considered to act by forming ion channels in cytoplasmic membranes of the victim cells. A functionally and structurally similar peptide named NK-lysin exists in mammalian lymphocytes. Several synthetic analogs of amoebapores and NK-lysin, which are substantially reduced in size compared to the parent molecules, were tested for their ability to inhibit the growth of and to kill Candida albicans. Some of the peptides displayed potent activity against a clinical isolate as well as against defined culture strains. Among the most active peptides found are some shortened substitution analogs of amoebapore C and a cationic core region of NK-lysin. As these peptides are also highly active against Gram-positive and Gram-negative bacteria but are of low cytotoxicity towards a human keratinocyte cell line they may provide promising templates for the design of broad-spectrum peptide antibiotics.

US$19.90

DOI: 10.1007/s004300050113


Other references

Sugita H.; Murakami K.; Sekiguchi K., 1985: The effects of salinity on embryonic development of the horseshoe crabs. Horseshoe crabs are found in coastal and estuarine areas and, when the tide is on the flow, the mature adults migrate shorewards to spawn on sandy beaches. The salinity measured was 18-33% in Tatara coast where Japanese horseshoe crabs were laying...

Weiermair, K.; Siller, H.J.; Mossenlechner, C., 2006: Entrepreneurs and entrepreneurship in Alpine tourism: past, present, and future. This paper addresses the need for more research in the field of entrepreneurial education in tourism, using the models of Butler's destination life cycle and Porter's diamond of competitive advantages. Entrepreneurship in tourism is disc...

Krejcova, H.; Pribyl, J.; Pribylova, J.; Stipkova, M.; Mielenz, N., 2008: Genetic evaluation of daily gains of dual-purpose bulls using a random regression model. Daily gains of 8 243 dual-purpose bulls from 100 to 400 days of age during the years 1971 to 2007 were analyzed by random regression models. Orthogonal Legendre polynomials (LP) of degree 4 were applied to daily gains calculated at 30-day interval...

Johnson A.C.; Vache K.; Edwards R., 2004: Ground saturation following various harvest patterns; implications of assessing a hydrologic model versus statistical analysis. Eos, Transactions, American Geophysical Union 85(47, Suppl

Potter, E.G.; Bebout, B.M.; Kelley, C.A., 2009: Isotopic composition of methane and inferred methanogenic substrates along a salinity gradient in a hypersaline microbial mat system. The importance of hypersaline environments over geological time, the discovery of similar habitats on Mars, and the importance of methane as a biosignature gas combine to compel an understanding of the factors important in controlling methane rele...

Alves, A.G.L.; Stewart, A.A.; Dudhia, J.; Kasashima, Y.; Goodship, A.E.; Smith, R.K.W., 2012: Cell-based therapies for tendon and ligament injuries. Tendon and ligament injuries have proved difficult to treat effectively. Cell-based therapies offer the potential to harness the complex protein synthetic machinery of the cell to induce a regenerative response rather than fibrous scarring. This a...

D.B.nedetto, F.; D.S.ndro, S.; D.R.vo, N.; Montalti, R.; Ballarin, R.; Guerrini, G.Piero.; Spaggiari, M.; Guaraldi, G.; Gerunda, G., 2010: First report on a series of HIV patients undergoing rapamycin monotherapy after liver transplantation. Some experimental trials have demonstrated that rapamycin (RAPA) is able to inhibit HIV-1 progression in three different ways: (1) reducing CCR5-gene transcription, (2) blocking interleukin-2 intracellular secondary messenger (mammalian target of...

Liu, C.; Cao, Y.; Liu, C.; Zhang, J.; Xu, P., 2012: Rapid maxillary anterior teeth retraction en masse by bone compression: a canine model. The present study sought to establish an animal model to study the feasibility and safety of rapid retraction of maxillary anterior teeth en masse aided by alveolar surgery in order to reduce orthodontic treatment time. Extraction of the maxillary...

Fersini, A., 1977: The Chironja, an experimental citrus. Tierra 32 (9) 389-390

Struzyńska, L.; Sułkowski, G.; Lenkiewicz, A.; Rafałowska, U., 2003: Lead stimulates the glutathione system in selective regions of rat brain. Lead (Pb) is a highly neurotoxic agent that causes functional and structural abnormalities in the brain. Glutathione (GSH) is a main molecule involved in the protection mechanisms against Pb itself and against reactive oxygen species generated by...