+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Central discriminative effects of morphine in rats: Training via intracerebroventricular administration

, : Central discriminative effects of morphine in rats: Training via intracerebroventricular administration. Brain Research Bulletin 56(6): 545-551, December

There have been studies of the discriminative effects of intracerebroventricularly (ICV)-administered morphine (MOR) in rats trained to discriminate MOR systemically, but the converse has not been done. In this study, rats were trained to discriminate between ICV (1-10 mug/3 mul, 1 h) or subcutaneous (SC) (3.0 mg/kg, 30 min) injections of MOR vs. saline/vehicle in a discrete-trial avoidance/escape procedure. On generalization testing, subjects in both the ICV- and SC-trained groups responded on the MOR-appropriate lever at ICV MOR doses ltoreq 1-3 mug, and at SC MOR doses 2 to 3 orders of magnitude higher (vs. ICV). Naltrexone (SC) blocked the stimulus effects of MOR (ICV) equipotently in both training groups. In ICV-trained subjects, levorphanol (SC), the mu-opioid selective peptide (D-Ala2, NMePhe4, Gly-ol)-enkephalin (DAMGO) (ICV), and the enkephalinase inhibitor N-(L-(1-carboxy-2-phenyl)ethyl)-L-phenylalanyl-beta-alanine (SCH 32615) (ICV) produced complete MOR-appropriate responding, whereas the dextrorotary enantiomer of levorphanol dextrorphan (SC; ltoreq 3.0 mg/kg) and the delta-opioid selective peptide (D-Pen2, D-Pen5)-enkephalin (DPDPE) (ICV, ltoreq 0.03 mg) did not. SC-trained subjects did not generalize to SCH 32615, which suggests qualitative differences in the discriminative stimulus effects of novel drugs as a function of the route of administration of the training drug. These data demonstrate that it is feasible to train rats to discriminate an opioid administered by the ICV route, and to perform extended tests of generalization to novel drugs (SC or ICV) in rats so trained.


DOI: 10.1016/s0361-9230(01)00661-x

Other references

Karakis, D.; Dogan, A., 2015: The craniofacial morphology and maximum bite force in sleep bruxism patients with signs and symptoms of temporomandibular disorders. The purpose of the present study was to compare craniofacial morphology and bite force of bruxist patients with signs and symptoms of temporomandibular disorders. Fourteen subjects with sleep bruxism and 14 healthy subjects participated. The signs...

Everts, H.B.; Jang, H.K.ung; Boston, R.C.; Canolty, N.L., 1995: Compartmental analysis dietary potassium and lithium turnover in rats. FASEB Journal 9(3): A455

Noe, B.D., 1981: Synthesis of one form of pancreatic islet somatostatin predominates. Journal of Biological Chemistry 256(18): 9397-9400

Johnson, S.R.; Mehta, S.; Granton, J.T., 2006: Anticoagulation in pulmonary arterial hypertension: a qualitative systematic review. Thrombotic arteriopathy has been implicated in the pathophysiology of pulmonary arterial hypertension (PAH). However, the role of anticoagulants in the treatment of PAH is uncertain. Through a qualitative systematic review of epidemiological studi...

Toke, C.; Jain, J.K., 2006: Understanding the 5/2 fractional quantum Hall effect without the Pfaffian wave function. It is demonstrated that an understanding of the 5/2 fractional quantum Hall effect can be achieved within the composite fermion theory without appealing to the Pfaffian wave function. The residual interaction between composite fermions plays a cru...

Just, J.; Grimfeld, A.; Tournier, G., 1988: Asthma in infants and children. La Revue du Praticien 38(2): 81-85

Bishu, S.; Quigley, J.M.; Bishu, S.R.; Olsasky, S.M.; Stem, R.A.; Shostrom, V.K.; Holdeman, K.P.; Paknikar, S.; Armitage, J.O.; Hankins, J.H., 2007: Predictive value and diagnostic accuracy of F-18-fluoro-deoxy-glucose positron emission tomography treated grade 1 and 2 follicular lymphoma. F-18-fluoro-deoxy-glucose positron emission tomography (PET) is a powerful tool for the imaging of aggressive B-cell lymphomas. In contrast, there is relatively little data on PET in follicular lymphoma grade 1 (FL-1) and grade 2 (FL-2). In this m...

Reich, J.M., 2016: Epidemiology of Sarcoidosis. Mayo Clinic Proceedings 91(6): 822-823

Hammond, E.C.; Hammond, E.C., 1988: Remarks on smoking: evidence and ethics. By E. Cuyler Hammond, 1971. Ca: A Cancer Journal for Clinicians 38(1): 59-60

Rosenblum, I.Y.; Benson, B.; Bria, C.F.; McDonnell, D.; Hruby, V.J., 1979: Localization and chemical characterization of a partially purified bovine pineal antigonadotropin. An antigonadotropic substance was partially purified from aqueous extracts of bovine pineal glands by methods of gel filtration, ultrafiltration and ion exchange chromatography. Two biological tests, viz. inhibition of compensatory ovarian hypertr...