geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Centrally mediated effect of 17beta-estradiol on parasympathetic tone in male rats


, : Centrally mediated effect of 17beta-estradiol on parasympathetic tone in male rats. American Journal of Physiology 276(2 Pt 2): R474-R481

The following experiments were conducted to determine if peripherally administered estrogen has an effect on central autonomic tone and whether this change in tone results in an alteration in cardiovascular reflex control. Male Sprague-Dawley rats were anesthetized with thiobutabarbitol sodium (50 mg/kg) and instrumented to record blood pressure, heart rate, and vagal parasympathetic or renal sympathetic efferent nerve activity. Additional rats were instrumented to test the sensitivity of the cardiac baroreflex using intravenous injections of phenylephrine hydrochloride (0.025, 0.05, 0.1 mg/kg) or sodium nitroprusside (0. 0025, 0.005, 0.01 mg/kg) and plotting the cardiovascular responses. Intravenous injection of estrogen (10(-4), 10(-2), and 10(-1) mg/kg) produced a significant increase in vagal efferent activity and in baroreflex sensitivity. The bilateral microinjection of an estrogen receptor antagonist, ICI-182,780 (1 pM, 50 nl/side) into the nucleus ambiguus blocked both the estrogen-induced increase in vagal efferent activity and baroreflex sensitivity. These results demonstrate that in male rats estrogen acts centrally to enhance baroreflex sensitivity by increasing parasympathetic efferent tone.

US$29.90

PMID: 9950927


Other references

Prell, H., 1923: On an Adaptation in some Insects which is favourable to others and an Examination of its Cause. The larvae of Lophyrus frutetorum, F., parasitized by Ceromasia (Lophyromyia) inchisa, Hart., make abnormal cocoons, and it is this that enables the fly to emerge. This has been regarded by some authors as a peculiar case of adaptation, when the h...

Cherrington, C.C.; Moser, D.K.; Lennie, T.A.; Kennedy, C.W., 2004: Illness representation after acute myocardial infarction: impact on in-hospital recovery. Despite significant progress in the treatment of coronary artery disease, myocardial infarction is still the leading cause of death in the United States. As suggested by Leventhal's Self-Regulation Model of Illness, the continued high morbidi...

Ivell, R.; Balvers, M.; Anand, R.J.K.; Paust, H-Joachim.; McKinnell, C.; Sharpe, R., 2003: Differentiation-dependent expression of 17beta-hydroxysteroid dehydrogenase, type 10, in the rodent testis: effect of aging in Leydig cells. Expression of the new 17beta-hydroxysteroid dehydrogenase (HSD), type 10 (17beta-HSD-10), formerly known as endoplasmic reticulum-associated amyloid-binding protein, has been investigated in the testes of various mammals under normal and perturbed...

Yoshida, Y.; Morimoto, Y., 1997: Measurement, modeling and seasonal changes of canopy photosynthesis in 'Nyoho' strawberry. The photosynthetic rate of a strawberry crop on a ground area basis was determined by measuring the changes in CO2 concentration in commercial greenhouses in Japan using the estimated rate of soil respiration and number of exchanges during the dar...

Bevan, D.R.; Garst, J.F.; Osborne, C.K.; Sims, A.M., 2006: Application of molecular modeling to analysis of inhibition of kinesin motor proteins of the BimC subfamily by monastrol and related compounds. Application of molecular modeling approaches has potential to contribute to rational drug design. These approaches may be especially useful when attempting to elucidate the structural features associated with novel drug targets. In this study, mol...

Boutrif, E., 1997: Establishing a food insecurity and vulnerability information and mapping system. A summary is presented of the outcome of a meeting in which the development of a Food Security and Vulnerability Information and Mapping System was discussed by representatives of the FAO and 8 other agencies, 5 national institutions, 2 non-govern...

Otto, K., 1966: Some results of examinations of children injured by their environment from the Erfurt Nerve Clinic. Psychiatrie, Neurologie, und Medizinische Psychologie 18(6): 223-226

Lawrence, R.M.; Biller, S.A.; Fryszman, O.M., 1995: Alpha-Phosphonosulfinic squalene synthetase inhibitors. Official Gazette of the United States Patent & Trademark Office Patents 1178(1): 336, Sept 5

Rondinone, B.Maria.; Persechino, B.; Castaldi, T.; Valenti, A.; Ferrante, P.; Ronchetti, M.; Iavicoli, S., 2013: Work-related stress risk assessment in Italy: the validation study of health safety and executive indicator tool. In compliance with the Italian occupational health and safety regulatory framework, as provided by the Lgs. Decree 81/2008, the "work-related stress" risk assessment should follow the same principles as other risk assessments, in accorda...

Kale, M.; Ata, A.; Yavru, S.; Yapkic, O.; Bulut, O.; Gulay, M.S., 2006: The effect of infection with bovine viral diarrhea virus on the fertility of cows and heifers. In the current study, blood samples from 319 cows and heifers were studied. Antibodies against BVDV infections in serum samples and BVDV antigens in leukocytes were present in 203 (148 cows and 55 heifers) and 56 (28 cows and 28 heifers) samples,...