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Cerebral blood flow predicts lesion growth in acute stroke patients


, : Cerebral blood flow predicts lesion growth in acute stroke patients. Stroke 33(10): 2421-2425

Background and Purpose: We sought to study the role of MRI-derived cerebral blood flow (CBF) measurements for the prediction of lesion development in acute stroke patients. Methods: Thirty-two patients were treated with tissue plasminogen activator. Diffusion-weighted (DWI) and perfusion-weighted MRI, T2-weighted imaging, and MR angiography were performed before treatment (2.8+-0.9 hours after symptom onset) and on follow-up (days 1 and 7). CBF thresholds (12 and 22 mL/100 g per minute) were applied to bolus tracking MRI maps to determine predictive cutoff levels. Results: In 21 patients (group A), the terminal lesion volume (T2-weighted imaging) was larger than the initial DWI lesion volume (89+-93 versus 21+-38 mL). In 11 patients (group B), the terminal lesion volume was smaller than the initial DWI lesion volume (7+-27 versus 15+-29 mL). The initial DWI lesion volume did not differ between both groups. The presence of a tissue volume gtoreq50 mL with a CBF value ltoreq12 mL/100 g per minute was predictive for lesion enlargement to day 7 in T2-weighted imaging (positive predictive value, 0.80). Conclusions: The presence of a tissue volume gtoreq50 mL with a CBF value ltoreq12 mL/100 g per minute predicts further lesion growth in hyperacute stroke patients. MRI-derived CBF values, with all their present limitations, are valuable in early estimation of prognosis of stroke patients.

US$29.90

PMID: 12364732


Other references

Pei Q.; Zetterstrom T.; Fillenz M., 1990: Effects of noradrenergic and cholinergic drugs on 5 ht release in hippocampus measured by microdialysis. European Journal of Pharmacology 183(5): 1919

Ferraz, M.B.; Berlin, J.; Paiva, J.G.; Atra, E., 1993: Do arthritis patients understand their prescriptions?. Lancet 341(8848): 833-834

Pimentel-Elardo, S.Marie.; Grozdanov, L.; Proksch, S.; Hentschel, U., 2012: Diversity of nonribosomal peptide synthetase genes in the microbial metagenomes of marine sponges. Genomic mining revealed one major nonribosomal peptide synthetase (NRPS) phylogenetic cluster in 12 marine sponge species, one ascidian, an actinobacterial isolate and seawater. Phylogenetic analysis predicts its taxonomic affiliation to the actin...

Oyama, T.; Miyata, Y.; Et-Al, 2005: The history of endoscopic treatment of the gastric cancer - From polypectomy to ESD. Endoscopic resection for gastric cancer was derived from polypectomy in 1968, but only protruded lesions Could be resected by the polypectomy method. So a kind of destruction method with laser irradiation was developed to treat flat lesions. The E...

Chen, C.; Xiao, Y., 2010: Accurate free energy calculation along optimized paths. The path-based methods of free energy calculation, such as thermodynamic integration and free energy perturbation, are simple in theory, but difficult in practice because in most cases smooth paths do not exist, especially for large molecules. In...

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