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Cholecystokinin/dopamine/GABA interactions in the nucleus accumbens: Biochemical and functional correlates

, : Cholecystokinin/dopamine/GABA interactions in the nucleus accumbens: Biochemical and functional correlates. Peptides (New York) 22(8): 1229-1234, August

The present article reviews our recent biochemical and microdialysis studies showing the evidence for an antagonistic CCK(B)/D(2) receptor interaction in the regulation of dopaminergic transmission in the nucleus accumbens and GABAergic transmission in the ipsilateral ventral pallidum. Since the nucleus accumbens plays a crucial role in regulating the output from the limbic system and consequently motivation, it may be speculated that a dysregulation of this receptor interaction may have consequences in a wide range of central nervous system disorders.


PMID: 11457515

DOI: 10.1016/s0196-9781(01)00446-6

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