+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Clinical characteristics of metachronous bilateral testicular tumors in the chemotherapeutic era

, : Clinical characteristics of metachronous bilateral testicular tumors in the chemotherapeutic era. Yonsei Medical Journal 40(2): 137-143

We wanted to present the results of our experience with bilateral testis tumor and to suggest the effects of chemotherapy in suppressing the development of second primary testicular tumors. Between 1978 and 1997, 2,345 patients were treated for testicular tumor at The University of Texas M. D. Anderson Cancer Center. Of these, 2,107 had germ cell cancers. There were 22 (0.94%) cases of bilateral testicular tumor in the overall patient population and 21 (1.0%) cases among patients with germ cell cancer. We reviewed the medical records to determine the incidence of the histological subtype, the incidence of metachronous versus synchronous formation of contralateral tumors, and tumor stage in this patient population. We also examined the effect of chemotherapy in treating the first tumor and preventing the occurrence of a second tumor. Finally, we compared the effect of ultrasonography, serum tumor marker elevation, and physical examination in detecting second tumors. Only one contralateral germ cell tumor developed synchronously; all others developed metachronously. Fifty percent of first tumors were seminomas, compared to 55% of second tumors. The histologic concordance rate for first and second tumors was 35%. Tumor stage was higher among first tumors than second tumors. The majority of second tumors in patients who received chemotherapy for first malignancies tended to be metachronous seminomas. Ultrasonography detected 6 of 21 (28.6%) contralateral tumors before they were evident by physical examination or serum tumor marker elevation. Seminomas were more prevalent among patients with bilateral germ cell disease than patients with unilateral disease. Chemotherapy, when used as treatment for first tumors, may have some effect in preventing the development of nonseminomatous germ cell tumors in the contralateral testicle. Close follow-up of the contralateral testis with ultrasonography is essential for early detection of second tumors. The outcome for patients with bilateral testicular germ cell cancer is excellent, secondary to early detection.


PMID: 10333717

DOI: 10.3349/ymj.1999.40.2.137

Other references

Sabatier, R.; Gonçalves, A.; Bertucci, Fçois.; Capiello, M-Antonietta.; Rousseau, Fédérique.; Lambaudie, E.; Chabannon, C.; Viens, P.; Extra, J-Marc., 2013: Are there candidates for high-dose chemotherapy in ovarian carcinoma?. Prognosis of advanced ovarian carcinomas (AOC) remains poor with a 5-year survival of 30%. Benefit from high-dose chemotherapy (HDC) in this disease has not been demonstrated to date. To evaluate the value of HDC as consolidation treatment after s...

Poel, L.; Van de., 1959: Fauna malacologique du Hervien, Troisieme note (premier et seconde partie). Bull Inst Sci nat Belg, 3515: 1-26

Skorkovská, S.; Janula, J.; Vlková, E., 1990: Binocular vision after intraocular lens implantation. The authors investigated the binocular function in a group of 127 patients after operation of cataract to whom an artificial intraocular lens was implanted. From the results ensues that adequate, or at least binocular vision satisfactory for human...

Zorick, T.S.; Gridley, T.; Lemke, G., 1997: Expression of the transcription factor SCIP in early postnatal Krox-20 deficient Schwann cells. Society for Neuroscience Abstracts 23(1-2): 1420

Chapyshev, S.V., 2016: Six-Membered Aromatic Polyazides: Synthesis and Application. Aromatic polyazides are widely used as starting materials in organic synthesis and photochemical studies, as well as photoresists in microelectronics and as cross-linking agents in polymer chemistry. Some aromatic polyazides possess high antitumor...

Saminathan, S.; Beijers, J.P.M.; Kremers, H.R.; Mironov, V.; Mulder, J.; Brandenburg, S., 2012: Optimization of a charge-state analyzer for electron cyclotron resonance ion source beams. A detailed experimental and simulation study of the extraction of a 24 keV He(+) beam from an ECR ion source and the subsequent beam transport through an analyzing magnet is presented. We find that such a slow ion beam is very sensitive to space-c...

Lavorini, F.; Geri, P.; Camiciottoli, G.; Pistolesi, M.; Fontana, G.A., 2007: Agreement between two methods for assessing bioequivalence of inhaled salbutamol. For inhaled medications, bioequivalence testing is becoming increasingly important owing to the availability of many inhalation devices. We evaluated agreement between the Finney bioassay and the Emax model in the assessment of bioequivalence of s...

Callan, B.E.; Ring, F.M., 1994: An annotated host fungus index for Populus in British Columbia. The index provides a reference for all documented fungal associations with Populus balsamifera, P. balsamifera subsp. trichocarpa [P. trichocarpa], Populus tremuloides, Populus sp., and hybrids between P. trichocarpa and P. deltoides or P. maximow...

Stagno, F.; Vigneri, P.; D.R.imondo, F., 2012: Clinical relevance of the association of interferon alfa to imatinib in chronic myeloid leukemia therapy. International Journal of Hematology 96(1): 142-143

Edwards, J.; Jannink, J., 2006: Bayesian modeling of heterogeneous error and genotype x environment interaction variances. An important assumption in the analysis of multienvironment cultivar trials is homogeneity of error and genotype x environment interaction variances. When variances are heterogeneous, the best estimators of performance are obtained by weighting in...