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Clinical study on combined LIFEIN with chemotherapy in the treatment of malignant tumors


, : Clinical study on combined LIFEIN with chemotherapy in the treatment of malignant tumors. Zhongguo Zhongliu Linchuang 28(7): 539-541

Objective: To evaluate the improvement of Immune function of patients after combined LIFEIN with chemotherapy and reducing its drug toxicity in treatment of malignant tumors. Methods: Seventy patients with various malignant tumors were randomized into two groups: Treatment group included 35 cases treated with LIFEIN plus chemotherapy (LIFEIN 5mg/d for three days was given hypodermically 3 day prior to the chemotherapy) followed with LIFEIN 5mg iv for 5 days and then 10mg iv for 20 days.), and 28 days was a therapeutic course. Another 35 cases as the control group was treated with single chemotherapy of same dosage. Results: 1) All patients of the treatment group had normal blood routines in the interval period of two cycles. In the control group, 4 cases had leucocytopenia of 4.0X10/mm3 and next chemotherapy was unable to be continued. G-CSF injection was used in another 12 cases for leucopenia lower than 3.0X10/mm3; 2) In the treatment group, nausea and vomiting happened in 68% of the patients during chemotherapy, and 94.2%(33/35) in the control group (P<0.05); 3) The values of CD4, CD4/CD8, CD56 significantly increased, while the values in the control group decreased markedly with significant difference between these two groups (P<0.05). Conclusion: LIFEIN can significantly reduce the side effects of chemotherapy, improve the life quality of patients, reduce the incidence of leucopenia to sustain the treatment and enhance the immune function of the patients.

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