geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Combination pharmacotherapy in children and adolescents with bipolar disorder


, : Combination pharmacotherapy in children and adolescents with bipolar disorder. Biological Psychiatry 53(11): 978-984, June 1

Background: The purpose of this study was to develop prospective data on the effectiveness of combination pharmacotherapy of children and adolescents with bipolar disorder during a 6-month period of prospective, semi-naturalistic treatment. Methods: Thirty-five subjects, with a mean age of 11 years, were treated in the extension phase of this study after having received 6-8 weeks of acute treatment with a single mood stabilizer. The extension phase of this study lasted for another 16 weeks, for a total of 24 weeks of prospective treatment. During this study phase, subjects were openly treated, and they could have their acute-phase mood stabilizer switched or augmented with another mood stabilizer, a stimulant, an antidepressant agent, or antipsychotic agent, if they were assessed to be a nonresponder to monotherapy with their initial mood stabilizer. Results: During the extension phase of treatment, 20 of 35 subjects (58%) required treatment with one or two mood stabilizers and either a stimulant, an atypical antipsychotic agent, or an antidepressant agent. The response rate to combination therapy was very good, with 80% of subjects treated responding to combination therapy with two mood stabilizers after not responding to monotherapy with a mood stabilizer. Conclusions: This study suggests that children and adolescents with bipolar disorder are similar to adults with bipolar disorder, who also frequently require combination therapy.

US$19.90

PMID: 12788243

DOI: 10.1016/s0006-3223(03)00067-2


Other references

Feldman, H.J., 1961: Value of hysterosalpingography for diagnosis and treatment of the "tubal factor" in infertility. Bulletin. Buffalo . Millard Fillmore Hospital 8: 27-36

Huang, W-Xian.; Min, J-Wei.; Liu, Y-Qiang.; He, X-Hua.; Peng, B-Wen., 2014: Expression of TRPV1 in the C57BL/6 mice brain hippocampus and cortex during development. Transient receptor potential vanilloid 1 (TRPV1) channel has been found to be expressed in a variety of tissues over the last few years, including the central nervous system (CNS). However, the distribution of TRPV1 in the CNS remains a controvers...

McFall, E., 1986: cis-acting proteins. Journal of Bacteriology 167(2): 429-432

Zimmerman S.C.; Lamberson C.R.; Cory M.; Fairley T.A., 1989: Topologically constrained bifunctional intercalators dna intercalation by a macrocyclic bisacridine. A topologically novel DNA bifunctional intercalator, 4, has been synthesized and its DNA binding compared with the binding of the monointercalator 9-aminoacridine (6) and spermine bisacridine (5), a known bisintercalator. Water-soluble macrocyclic...

Kondo S.; Sugiura K.; Ohwaki K.; Yabe Y., 1969: Some newer concepts on pneumo encephalography. International Congress Series : 138

Tamasige, M., 1958: Nerve-supplied single muscle fibre. Journal of the Faculty of Science Hokkaido University Zoology, 13: 475-478

Bennett, J.; Azhar, N.; Rahim, F.; Kamil, S.; Traverso, H.; Killgore, G.; Boring, J., 1995: Further observations on ghee as a risk factor for neonatal tetanus. Previous investigations in Pakistan revealed that the application of ghee (clarified butter) to umbilical wounds is a risk factor for neonatal tetanus (NNT), but the underlying mechanisms remained unknown because multiple cultures of ghee obtained...

Crombie, RI.; Heyer, WR., 1983: Leptodactylus longirostris (Anura: Leptodactylidae): advertisement call, tadpole, ecological and distributional notes. Differences in morphology and advertisement call between Brazilian and Venezuelan/Guianan populations of L. longirostris Boulenger are examined and the variation falls within the limits of a single biological species. New records confirm the prese...

Bhosale R.J.; Andhale R.K., 1979: Performance of mung phaseolus aureus varieties under various levels of row spacing and varying dates of sowing. Field experiments were conducted on lateritic soils. The mung variety Hy-45 registered a mean grain yield of 8.26 q[quintals]/ha, followed by T-44 (7.45 q/ha) and J-781 (6.64 q/ha). Sowing of mung on Dec. 1st at a row spacing of 22.5 cm increased...

Kimanya, M.E.; D.M.ulenaer, B.; Roberfroid, D.; Lachat, C.; Kolsteren, P., 2011: Fumonisin exposure through maize in complementary foods is inversely associated with linear growth of infants in Tanzania. Infants consuming maize-based foods are at a high risk of exposure to fumonisins. This study explored the association between exposure of fumonisins from maize and growth retardation among infants in Tanzania. Mothers of 215 infants consented for...