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Commentary: Is the concept of Tumor Promotion a useful paradigm?


, : Commentary: Is the concept of Tumor Promotion a useful paradigm?. Molecular Carcinogenesis 30(3): 131-137, March

Since the demonstration of the multistage nature of carcinogenesis in experimental work on mouse skin carcinogenesis (and subsequently on various other organ systems in other organisms), the concepts of "initiation", "promotion", and "progression" were operationally generated from empiric data. Because these early observations and concepts had no mechanistic explanations, various hypotheses have been generated to explain the unique characteristics of each phase (e.g., initiation, being irreversible, was ascribed as the result of DNA damage leading to mutagenesis; promotion, being interruptible or reversible, was believed to be caused by epigenetic mechanisms; progression, also being irreversible, was believed to be caused by genetic instability that led to mutagenic and epigenetic changes). In addition, many of the molecular, biochemical, and cellular experiments designed to investigate the mechanistic bases of these phases used technologies that did not always lead to unequivocal interpretations, and because "real-life" carcinogenesis does not mimic controlled experimental conditions of the initiation/promotion/progression experiments, many investigators believe that these concepts have lost their usefulness. In this commentary, I explain some of the confusion concerning the concept of promotion and suggest that, by understanding the limitations of many in vitro assays used to characterize mutagens, by integrating other theories of carcinogenesis (i.e., stem cell theory), and by recognizing the role of epigenetic agents, specifically, modulated gap-junctional intercellular communication, the concept of promotion can provide valuable insights into the carcinogenic process. Mol. Carcinog. 30:131--137, 2001.

US$19.90

PMID: 11301473

DOI: 10.1002/mc.1021


Other references

Kokh, A., 1971: Possible relation between the level of poliovirus multiplication and conformation of cation-carrying ATPase of host cells. Voprosy Virusologii 16(5): 627-629

Van Houtte, P.; Roelandts, M.; Kantor, G., 2014: Radiotherapy indications for non-malignant diseases in 2014. This review updates the radiotherapy indications for non-malignant diseases, except those treated by radiosurgery. Since the last 2005 review, there have been no major changes in the indications: the prevention of heteropic bone formation and kelo...

Covington, C.; Nordstrom-Klee, B.; Delaney-Black, V.; Templin, T.; Ager, J.; Sokol, R.J., 2002: Development of an Instrument to Assess Problem Behavior in First Grade Students Prenatally Exposed to Cocaine. Part II: Validation. In Part I, the initial development of a preliminary tool, the PROBS-14, was reported. The tool was developed and initially tested through a consensus process that tapped the perceptions of early education teachers. Concurrent validity between the...

Gresswell R.Kay, 1962: The glaciology of the Coniston Basin. Although the Coniston basin, northwest England, had a continuous ice cover during earlier glaciations, it was the late phases of the Newer glaciation that had the greater effect on the topography. The main Coniston glacier subdivided south of Coni...

Watanabe, I.; Watanabe, T.; Inahama, Y.; Osone, M.; Machida, Y., 1967: Clinico-pathological study on the effects of gold and silver on dental pulp. Shika Gakuho. Dental Science Reports 67(5): 667-674

Tuckey, N.P.L.; Forster, M.E.; Gieseg, S.P., 2010: Effects of rested harvesting on muscle metabolite concentrations and K-values in Chinook salmon (Oncorhynchus tshawytscha) fillets during storage at 15 degrees C. Improvement of harvesting procedures in aquaculture may also improve the quality and storage properties of the fish. The use of an anesthetic allows fish to be harvested with reduced stress and exhaustion, which affect fillet properties. We report...

Skotnicki, M.L.; Mo, J.Q., 1996: Detection of cardamine chlorotic fleck carmovirus in soil by the polymerase chain reaction. Cardamine chlorotic fleck carmovirus (CCFV) has been found only in plants of Cardamine lilacina in the Kosciusko alpine area of Australia. CCFV was detected in infected plants by the polymerase chain reaction (PCR); the number and sizes of DNA ban...

Arkin, J.A., 1968: Why buy Mutual fund at "ex-dividend" price?. Dental Survey 44(2): 77-77

Shi, W.; Zhang, Z.; Zhang, M.; Liu, J.; Jiang, Y.; Wang, Y.; Jin, X.; Han, X.; Shang, H., 2009: The frequency, activation, and coreceptor expression of lymphocytes in human immunodeficiency virus/hepatitis C virus co-infected patients in China. The purpose of this study was to characterize the frequency, activation, and coreceptor expression of lymphocytes in Chinese human immunodeficiency virus (HIV)/hepatitis C virus (HCV) co-infected patients, and to study the impact of HCV on immune...

Sharrock, N.E., 1980: Postural headache following thoracic somatic paravertebral nerve block. Anesthesiology 52(4): 360-362