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Composite interval mapping of quantitative trait loci with granddaughter design

, : Composite interval mapping of quantitative trait loci with granddaughter design. Korean Journal of Genetics ch; 25(1): 41-45

For outcrossing species with limited female fertility, granddaughter design has been effective to map quantitative trait loci (QTLs). In the design, the sons of informative grandfathers who are heterozygous for the genetic markers are genotyped, and phenotypes of quantitative traits are recorded on the daughters of these sons. The composite interval mapping (CIM) with the granddaughter design to identify QTLs was empirically evaluated through the simulation in this study. The estimates of likelihood ratios, QTL effects, and linkage positions were better in the populations with a larger family size, but the differences were not large, which implied that the QTL detection did not largely depend on the family size. On the other hand, QTL mapping significantly depended on the number of families in the population. And, the balanced design performed better than the unbalanced. One of the two QTLs simulated in the current study was not detected in the unbalanced population with the heritability of 0.3. This recommended that, in order to detect QTLs, the design should not be used in the population when the heritability was 0.3 or lower. This study also showed that a higher level of heritability led to more significant likelihood ratios and more accurate estimates of QTL effects and positions, enhancing the ability to identify QTLs. Also, precision of the estimates was improved with a large heritability.


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