geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state


, : Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state. Journal of Experimental Medicine 198(5): 737-746

Despite a growing interest in CD4+ CD25+ regulatory T cells (Treg) that play a major role in self-tolerance and immunoregulation, fundamental parameters of the biology and homeostasis of these cells are poorly known. Here, we show that this population is composed of two Treg subsets that have distinct phenotypes and homeostasis in normal unmanipulated mice. In the steady state, some Treg remain quiescent and have a long lifespan, in the order of months, whereas the other Treg are dividing extensively and express multiple activation markers. After adoptive transfer, tissue-specific Treg rapidly divide and expand preferentially in lymph nodes draining their "target self-antigens. These results reveal the existence of a cycling Treg subset composed of autoreactive Treg that are continuously activated by tissue self-antigens.

US$19.90

PMID: 12939344

DOI: 10.1084/jem.20030686


Other references

Andrykowski, M.A.; Otis, M.L., 1990: Development of learned food aversions in humans: investigation in a natural laboratory of cancer chemotherapy. Humans often develop learned food aversions (LFAs) to foods or beverages consumed in temporal contiguity to gastrointestinal distress. Viewed as a classical conditioning process, principles of LFA development have been studied in the animal labora...

Hamaguchi, M.; Muraoka, A.; Tanaka, T.; Kusuda, R., 1989: A method for determination of intracellular bacterial killing by yellowtail phagocytic cells againsts Pasteurella piscicida. Bulletin of the Japanese Society of Scientific Fisheries 55.6: 971-977

Massie, M.T.; Darrell, J.C.; DiMarco, R.F.; Marrangoni, A.G.; Wei, L.M.; Miller, S.; Woelfel, G.F.; Pellegrini, R.V., 1993: Normothermic retrograde continuous cardioplegia for myocardial protection during cardiopulmonary bypass. A modified technique. Normothermic retrograde continuous cardioplegia is a revolutionary development for myocardial preservation in cardiac surgery. Despite excellent reports regarding this technique, the surgical community has expressed concern over technical problems...

Finset, A., 2016: Silence is golden. Patient Education and Counseling 99(10): 1545-1546

Nakayama, T.; Hirano, K.; Nishimura, J.; Kanaide, H., 2001: Regulation of PAR1 by trypsin in vascular endothelial cells. Japanese Journal of Pharmacology 85(Supplement 1): 64P

Burttet, L.Medeiros.; Varaschin, G.Aguiar.; Berger, A.Kives.; Cavazzola, L.Totti.; Berger, M.; Silva, B., 2017: Prospective evaluation of vesicourethral anastomosis outcomes in robotic radical prostatectomy during early experience in a university hospital. Robotic assisted radical prostatectomy (RARP) presents challenges for the surgeon, especially during the initial learning curve. We aimed to evaluate early and mid-term functional outcomes and complications related to vesicourethral anastomosis (V...

Beu, Alan, G., 2001: Gradual Miocene to Pleistocene uplift of the Central American isthmus: Evidence from tropical American tonnoidean gastropods. Tonnoidean gastropods have planktotrophic larval lives of up to a year and are widely dispersed in ocean currents; the larvae maintain genetic exchange between adult populations. They therefore are expected to respond rapidly to new geographic bar...

Magaña Pintiado, M.I.; Al-Kassam Martínez, M.; Bousoño García, C.; Ramos Polo, E.; Gómez Alvarez, M.E., 2009: The megacystis-microcolon-intestinal hypoperistalsis syndrome: apropos of a case with prolonged survival. Megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is a severe congenital disease with autosomal recessive inheritance, characterized by vesical distension and intestinal hypoperistalsis what causes intestinal obstruction in newborn...

Laterre, P-François.; Wittebole, X.; Van de Velde, S.; Muller, A.E.; Mouton, J.W.; Carryn, Séphane.; Tulkens, P.M.; Dugernier, T., 2015: Temocillin (6 g daily) in critically ill patients: continuous infusion versus three times daily administration. The growing incidence of infections caused by Enterobacteriaceae producing ESBLs has led to increased use of carbapenems. Temocillin, which resists most β-lactamases, may be a useful alternative. The aim of this study was to assess the pharmacoki...

Forster, F.M.; Fabing, H.D., 1971: Howard D. Fabing, 1907-1970. Transactions of the American Neurological Association 96: 342-344