geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Contribution of central sensitisation to the development of non-cardiac chest pain


, : Contribution of central sensitisation to the development of non-cardiac chest pain. Lancet 356(9236): 1154-1159

Background Non-cardiac chest pain mimics angina pectoris but generally originates from the oesophagus. Visceral hypersensitivity may contribute, but its neurophysiological basis is unclear. We investigated whether central sensitisation, an activity-dependent amplification of sensory transfer in the central nervous system, underlies visceral pain hypersensitivity and non-cardiac chest pain. Methods We studied 19 healthy volunteers and seven patients with non-cardiac chest pain. Acid was infused into the lower oesophagus. Sensory responses to electrical stimulation were monitored within the acid-exposed lower oesophagus, the non-exposed upper oesophagus, and the cutaneous area of pain referral, before and after the infusion. Findings In healthy volunteers, acid infusion into the lower oesophagus lowered the pain threshold in the upper oesophagus (mean decrease 18.2% (95% CI 10.4 to 26.0); p=0.01) and on the chest wall (24.5% (10.2 to 38.7); p=0.01). Patients with non-cardiac chest pain had a lower resting oesophageal pain threshold than healthy controls (45 (30 to 58) vs 64 (49 to 81) mA; p=0.04). In response to acid infusion, their pain threshold in the upper oesophagus fell further and for longer (mean fall in area under threshold/time curve 26.7 (11.0 to 42.3) vs 5.8 (2.8 to 8.8) units; p=0.04). Interpretation The finding of secondary viscerovisceral and viscerosomatic pain hypersensitivity suggests that central sensitisation may contribute to visceral pain disorders. The prolonged visceral pain hypersensitivity in patients with non-cardiac chest pain suggests a central enhancement of sensory transfer. New therapeutic opportunities are therefore possible.

US$19.90

PMID: 11030295

DOI: 10.1016/S0140-6736(00)02758-6


Other references

Smith, E.L.IIi, 1998: Performance characteristics of the emmetropization process in macaque monkeys. IOVS 39(4): S460, March 15

Mantrova, Ez, 1977: Effect of different levels of fertilizers on ornamental characters of true rooted roses during the first years of their life. Agrokhimiia 8 95-101

Bacciarelli, C.; Boni, P.; Castellucci, A., 1978: Antilipolytic effect of tiadenol and clofibrate in rat epididymal fat pads. Il Farmaco; Edizione Pratica 33(9): 401-406

D.F.anco, M.; Barchetta, I.; Iannuccelli, C.; Gerardi, M.Chiara.; Frisenda, S.; Ceccarelli, F.; Valesini, G.; Cavallo, M.Gisella., 2016: Hypovitaminosis D in recent onset rheumatoid arthritis is predictive of reduced response to treatment and increased disease activity: a 12 month follow-up study. Bmc Musculoskeletal Disorders 16: 53-53

Rhode, K., 1993: Profile: Carl Asmund Rudolphi (1771-1832). A brief review of the life and work of the German helminthologist Carl Asmund Rudolphi (1771-1832) is given. Rudolphi, who was born in Sweden, has been called the "Father of Helminthology" and the "Linnaeus of Helminthology". M...

Ghoneim, S.; Rapp, J.P.; Mark, A.L.; Baumbach, G.I., 1995: Remodeling of cerebral arterioles in Dahl S/JR hypertensive rats. FASEB Journal 9(3): A52

Fraser, G., 1984: Hererocallis production and cultivation. Combined proceedings International Plant Propagators' Societyub 1984) 33(33): 546

Landesman, W., 2010: Acute appendicitis treated with penicillin. United States Naval Medical Bulletin 46: 1474-1474

Palmieri M.D.; Fritz J.S., 1987: Determination of metal ions by high performance liquid chromatographic separation of their hydroxamic acid chelates. Metal ions are determined by adding N-methylfurohydroxamic acid to an aqeous sample and then separating the metal chelates by direct injection onto a liquid chromatographic column. Separations on a C8 silica column and a polystyrene-divinylbenzene...

McConnel, C.S.; Shum, L.; House, J.K., 2007: Infectious bovine keratoconjunctivitis antimicrobial therapy. Infectious bovine keratoconjunctivitis (IBK) is one of the most common diseases of cattle and is of major economic importance. If the primary aetiological agent, Moraxella bovis, is successfully eliminated from ocular tissues corneal ulcers heal...