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Correlation study between expression of MHC I molecule in ovarian carcinoma and T-cell infiltration in vivo on ovarian carcinoma milieu


, : Correlation study between expression of MHC I molecule in ovarian carcinoma and T-cell infiltration in vivo on ovarian carcinoma milieu. Journal of Shanghai Medical University 27(3): 201-203, 207, May

Purpose: To determine the correlation between expression of MHC class I on ovarian tumor cells and T-cell infiltration in vivo on ovarian tumor micro-environment. Methods: Thirty three samples of primary epithelial ovarian carcers were analysed with flow cytometry for MHC class I expression. Immunohistochemical analysis was performed using monoclonal antibodies that recognize leukocyte differentiation antigens (LCA+, CD3+) on cryostat sections of primary epithelial ovarian carcinoma. The results were compared with the expression of MHC class I expression. Results: Close correlation were revealed bewteen the expression of MHC class I molecules and the numbers of infiltrating LCA+ positive cells (r=0.846, P=0.000 1) and CD3+ cells (r=0.738, P=0.000 1). Conclusions: Expression of MHC class I molecules may influence the status of human immunosurveillance in tumor micro-environment on ovarian carcinoma and the assay may be helpful in selection patients for adoptive immnotherapy.

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Other references

Hopkins, W.B., 1898: V. Osteotomoclasis: A Preliminary Note on a Modified Operation to Correct Curved Tibia. Annals of Surgery 28(1): 120-124

Nakahara, K., 1978: Special features of intestinal metaplasia and its relation to early gastric carcinoma in man: observation by a method in which leucine aminopeptidase activity is used. The degree of intestinal metaplasia and its macroscopic distribution in gastric mucosa were examined by a new method in which leucine aminopeptidase (LAP) activity is used to investigate the relationship between intestinal metaplasia and gastric c...

Reynaert, N.; Vandenberghe, P.; Boeckx, N.; Renard, M.; Uyttebroeck, A.; Labarque, V., 2015: Translocation t(1;11)(q21;q23): a new finding in congenital acute myeloid leukemia. Leukemia & Lymphoma 55(6): 1435-1436

Saratikov, A.S.; Prishchep, T.P.; Stepnova, G.M.; Shmidt, E.V.; Borisova, G.V., 1972: The pharmacologic properties of stearic acid antipyrylamide (stampyrine). Farmakologiia i Toksikologiia 35(6): 723-727

Gastellu, J.R.ynaud, M., 1994: Pathogenicity of Eimeria mulardi Chauve et al., 1994, in experimentally infected mule-ducks. Details of the pathological stages. Avian pathology 23(3): 557-568

Spencer, J.; Hersch, G.; Shelton, M.; Ripple, J.; Spencer, C.; Dyer, C.B.; Murphy, K., 2002: Functional outcomes and daily life activities of African-American elders after hospitalization. African-American elders were recruited from a transitional unit after hospitalization and tracked for 6 months in the community after discharge to (a) examine functional outcomes on the unit and in the community and (b) identify patterns of partic...

Chin, C.N., 1953: The unhospitalized tuberculosis patient: nursing problem. Transactions of the Annual Meeting. National Tuberculosis Association 49: 458-461

Luque-De-Castro, M.D.; Fernandez-Romero, J.M.; Quiles, R., 1995: Determination of inorganic ions of clinical interest: State-of-the-art and trends. An overview is presented of techniques, analysers and methods currently available for the determination of inorganic ions of interest in clinical laboratories; methods include those based on activation and inhibition of enzymatic reactions by thes...

Hanslik, A.; Moysich, A.; Laser, K.Thorsten.; Mlczoch, E.; Kececioglu, D.; Haas, N.A., 2014: Percutaneous closure of atrial septal defects in spontaneously breathing children under deep sedation: a feasible and safe concept. Interventional cardiac catheterization in children and adolescents is traditionally performed with the patient under general anesthesia and endotracheal intubation. However, percutaneous closure of atrial septum defect (ASD) without general anaest...

Zimmermann E., 1991: Ontogeny of acoustic communication in prosimian primates. Ehara, A , Et Al (Ed ) Primatology Today; Xiiith Congress Of The International Primatological Society, Nagoya And Kyoto, Japan, July 18-24, 1990 Xxv+732p Elsevier Science Publishers B V : Amsterdam, Netherlands; (Dist in The Usa And Canada By Elsevier Science Publishing Co , Inc : New York, New York, Usa) Illus Maps 337-340