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Correlation study between expression of MHC I molecule in ovarian carcinoma and T-cell infiltration in vivo on ovarian carcinoma milieu

, : Correlation study between expression of MHC I molecule in ovarian carcinoma and T-cell infiltration in vivo on ovarian carcinoma milieu. Journal of Shanghai Medical University 27(3): 201-203, 207, May

Purpose: To determine the correlation between expression of MHC class I on ovarian tumor cells and T-cell infiltration in vivo on ovarian tumor micro-environment. Methods: Thirty three samples of primary epithelial ovarian carcers were analysed with flow cytometry for MHC class I expression. Immunohistochemical analysis was performed using monoclonal antibodies that recognize leukocyte differentiation antigens (LCA+, CD3+) on cryostat sections of primary epithelial ovarian carcinoma. The results were compared with the expression of MHC class I expression. Results: Close correlation were revealed bewteen the expression of MHC class I molecules and the numbers of infiltrating LCA+ positive cells (r=0.846, P=0.000 1) and CD3+ cells (r=0.738, P=0.000 1). Conclusions: Expression of MHC class I molecules may influence the status of human immunosurveillance in tumor micro-environment on ovarian carcinoma and the assay may be helpful in selection patients for adoptive immnotherapy.


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