+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Cortical neurons require Otx1 for the refinement of exuberant axonal projections to subcortical targets

, : Cortical neurons require Otx1 for the refinement of exuberant axonal projections to subcortical targets. Neuron 24(4): 819-831, Dec

Information processing in the nervous system depends on the creation of specific synaptic connections between neurons and targets during development. The homeodomain transcription factor Otx1 is expressed in early-generated neurons of the developing cerebral cortex. Within layer 5, Otx1 is expressed by neurons with subcortical axonal projections to the midbrain and spinal cord. Otx1 is also expressed in the precursors of these neurons, but is localized to the cytoplasm. Nuclear translocation of Otx1 occurs when layer 5 neurons enter a period of axonal refinement and eliminate a subset of their long-distance projections. Otx1 mutant mice are defective in the refinement of these exuberant projections, suggesting that Otx1 is required for the development of normal axonal connectivity and the generation of coordinated motor behavior.


DOI: 10.1016/s0896-6273(00)81030-2

Other references

Krüger, K.E.; Thiele, I., 1965: Congenital stenoses of the lacrimal apparatus. Zeitschrift für Arztliche Fortbildung 59(9): 500-503

Robinson S.E., 1984: Symposium on nonadrenergic central control of blood pressure held at the 66th annual meeting of the federation of american societies for experimental biology new orleans louisiana usa april 22 1982. Federation Proceedings 43(1): 16-44

Overgaauw, P., 2007: Gastrointestinal problems in cats and dogs with chronic diarrhea. Tijdschrift Voor Diergeneeskunde 132(3): 107-108

Lobockaja, L.I.; Bycko, E.A.; Pal'cenko, L.A.; Bormotov, V.E., 1968: Peroxi-dase activity and respiration rate in sugar-beet plants differing in degree of ploidy. The leaves and roots of tetraploid forms and triploid hybrids had lower peroxidase activities than diploid varieties In the course of stabilization of the tetraploid analogues, the relative difference in peroxidase activity compared with diploid v...

Schankula, H.J., 1962: A booklet for the patient-its effectiveness and composition. Canadian Hospital 39: 68 Passim-68 Passim

Wing S.L., 1996: Pulsed change in composition of floras during the Paleocene-Eocene transition. Special Publication - The Paleontological Society 8: 425

Martin Dippe; Regina Schoeps; Renate Ulbrich-Hofmann, 2007: Modulation of the transphosphatidylation potential of phospholipase D by protein and medium engineering. Chemistry and Physics of Lipids 149(supp-S): 0-0

Kelly, Graham Edmund, 2001: Process for glucan preparation and therapeutic uses of glucan. A process for the production of beta-3-(1,3)(1,6) glucan from a glucan containing cellular source is described, together with compositions and uses/methods of treatment involving glucan. The process of the invention comprises the steps of: (a) ext...

McIntyre S., 1991: Mineral Sands WIM 150. JB

Sorkin, L.S.; Jones, D.L.; Isakson, P., 1996: Timing and route of NSAID administration affects basal and NMDA-evoked spinal levels of PGE2 and amino acids. Society for Neuroscience Abstracts 22(1-3): 1813