geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Cutting edge: molecular portrait of human autoimmune disease


, : Cutting edge: molecular portrait of human autoimmune disease. Journal of Immunology 169(1): 5-9

Autoimmune diseases affect 3-5% of the population, are mediated by the immune response to self-Ags, and are characterized by the site of tissue destruction. We compared expression levels of >4,000 genes in PBMC of control individuals before and after immunization to those of individuals with four distinct autoimmune diseases. The gene expression profile of the normal immune response exhibits coordinate changes in expression of genes with related functions over time. In contrast, each individual from all autoimmune diseases displays a similar gene expression profile unrelated to the pattern of the immunized group. To our surprise, genes with a distinct expression pattern in autoimmunity are not necessarily "immune response" genes, but are genes that encode proteins involved in apoptosis, cell cycle progression, cell differentiation, and cell migration.

US$19.90

PMID: 12077221

DOI: 10.4049/jimmunol.169.1.5


Other references

Michie, S.; Dormandy, E.; Marteau, T.M., 2003: Informed choice: understanding knowledge in the context of screening uptake. This study evaluates a scale measuring knowledge about a screening test and investigates the association between knowledge, uptake and attitudes towards screening. One thousand four hundred ninety-nine pregnant women completed the knowledge scale...

Wiesik-Szewczyk, E.; Olesinska, M., 2012: B-cell targeted therapy in systemic lupus erythematosus: potential of rituximab. Systemic lupus erythematosus (SLE) is a complex autoimmune disease of unknown etiology, and the limited available therapeutic options for this disease, are frustrating to both clinicians and patients. However, recent advances in the understanding...

Morel, L.; Fontana, E.; Michel, J-Marie.; Ruffieux, Aé.; Ottiger, M.; Regamey, C., 2007: A new treatment: bariatric surgery; a new complication: Wernicke-Korsakoff encephalopathy. Bariatric surgery has peripheral or central neurological complications in 5-10% of patients. We report the case of a 39-year-old man with metabolic syndrome who underwent gastric by-pass surgery and then lost 40 kg over a period of 2.5 months. He...

Hitze, K.L., 1973: Preliminary report of the WHO seminar on the evaluation of tuberculosis prevention. Bulletin of the International Union Against Tuberculosis 48(0): 60-63

Parrish, A.; Zikira, M.; Tomacelli, C.; Kenney, R., 1990: Carbohydrate utilization in exercising muscle in subtotally nephrectomized rabbits. Subtotally nephrectomized rabbits were compared with sham-operated controls. The isolated soleus muscle of one leg was exercise dusing controlled stimulus parameters at 1 Hz until the contraction tension (amplitude) was reduced by one half. The mu...

Voreades, N.; Kozil, A.; Weir, T.L., 2014: Diet and the development of the human intestinal microbiome. The important role of the gut microbiome in maintaining human health has necessitated a better understanding of the temporal dynamics of intestinal microbial communities as well as the host and environmental factors driving these dynamics. Genetic...

Bentue-Ferrer, D.; Decombe, R.; Saiag, B.; Allain, H., 1992: Pharmacology of cellular ischemia. Knowledge of cellular disturbances provoked by an ischemic aggression conditions the use of a pharmacologic strategy that could possibly protect the cell from necrosis. Whatever the type of cell, the basic mechanisms are very similar: energy failu...

Maloletko A.M., 1968: Eocene terrestrial bauxitic deposits in the Biisk-Barnaul basin. Lake-swamp origin, gibbsitic clays, Eocene palynomorphs, noncommerical because of small size and great depth, USSR, southwest Siberia.

Hardy, J.D., 1970: The first heart transplant in man: brief review with notes on a more recent case. Laval Medical 41(2): 113-118

Arshad Javaid; Shazia Shafique; Sobiya Shafique, 2006: Fungi associated with stored seeds of Parthenium hysterophorus collected from Lahore. The present study reports the fungi associated with stored seeds of an alien weed Parthenium hysterophorus collected from Lahore (Punjab, India) from February to June 2006. Experiment was conducted on July 2006. A total of three fungal species nam...